The MMP21 Polyclonal Antibody (PACO18229) is a valuable tool for research involving Matrix metalloproteinase-21 (MMP21), an enzyme that plays a critical role in extracellular matrix remodeling and tissue homeostasis. This polyclonal antibody, generated in rabbits, exhibits high specificity and reactivity towards MMP21 in human samples, making it suitable for use in various research applications, including Western blotting.MMP21 is a proteolytic enzyme that is involved in the degradation and remodeling of extracellular matrix components, such as collagens, and is known to be dysregulated in various diseases, including cancer and inflammatory disorders. By targeting MMP21 with this antibody, researchers can study its expression patterns and activity in different cell types, providing valuable insights into its role in disease progression and potential therapeutic targeting.
With its high specificity and reliability in detecting MMP21, the PACO18229 antibody is an essential tool for researchers in the fields of molecular biology, cancer research, and tissue remodeling studies. By facilitating the detection and analysis of MMP21, this antibody enables a deeper understanding of the enzyme's function and its implications in pathological conditions, ultimately advancing research towards the development of novel therapeutic interventions.
Antibody Name:
MMP21 Antibody (PACO18229)
Antibody SKU:
PACO18229
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human MMP21
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO18229(MMP21 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling,and disease processes, such as asthma and metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival.
Synonyms:
matrix metallopeptidase 21
UniProt Protein Function:
MMP21: May have an important and specific function in tumor progression and embryogenesis. Cleaves alpha-1-antitrypsin. Belongs to the peptidase M10A family.Protein type: EC 3.4.24.-; Secreted, signal peptide; Secreted; ProteaseChromosomal Location of Human Ortholog: 10q26.13Cellular Component: extracellular matrix; extracellular regionMolecular Function: zinc ion binding; metalloendopeptidase activity; calcium ion bindingBiological Process: hemopoietic progenitor cell differentiation; proteolysis
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, and disease processes, such as asthma and tumor metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival. [provided by RefSeq, May 2013]
