The MMP21 Polyclonal Antibody (PACO18230) is a valuable tool for researchers studying Matrix Metalloproteinase 21 (MMP21), a key enzyme involved in extracellular matrix remodeling and tissue homeostasis. MMP21 plays a crucial role in various physiological processes, including cell migration, wound healing, and tissue development.This polyclonal antibody, generated in rabbits, is highly specific and reacts with MMP21 in human samples. Validated for use in Western blot applications, this antibody allows for the detection and analysis of MMP21 expression levels in a variety of cell types and tissues.
Its versatility and reliability make it an ideal choice for studies in cell biology, tissue engineering, and cancer research.Given its importance in extracellular matrix dynamics and tissue remodeling, understanding the function and regulation of MMP21 is essential for developing therapies targeting diseases such as cancer, fibrosis, and inflammatory disorders. The MMP21 Polyclonal Antibody provides researchers with a valuable tool to further explore the roles of MMP21 in health and disease, paving the way for innovative therapeutic strategies and potential clinical applications.
Antibody Name:
MMP21 Antibody (PACO18230)
Antibody SKU:
PACO18230
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human MMP21
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO18230(MMP21 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO18230(MMP21 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling,and disease processes, such as asthma and metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival.
Synonyms:
matrix metallopeptidase 21
UniProt Protein Function:
MMP21: May have an important and specific function in tumor progression and embryogenesis. Cleaves alpha-1-antitrypsin. Belongs to the peptidase M10A family.Protein type: EC 3.4.24.-; Secreted, signal peptide; Secreted; ProteaseChromosomal Location of Human Ortholog: 10q26.13Cellular Component: extracellular matrix; extracellular regionMolecular Function: zinc ion binding; metalloendopeptidase activity; calcium ion bindingBiological Process: hemopoietic progenitor cell differentiation; proteolysis
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, and disease processes, such as asthma and tumor metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival. [provided by RefSeq, May 2013]
