The MMP23A Monoclonal Antibody (PAC02030) is a cutting-edge tool for researchers studying MMP23A, a matrix metalloproteinase enzyme involved in extracellular matrix remodeling and tissue repair. This antibody, produced through a specialized monoclonal process, exhibits high specificity and sensitivity for detecting MMP23A in various biological samples, making it an invaluable asset in experiments such as Western blotting and immunohistochemistry.MMP23A, a member of the matrix metalloproteinase family, plays a key role in physiological processes such as wound healing, angiogenesis, and tissue remodeling.
Dysregulation of MMP23A expression has been linked to diseases like cancer, arthritis, and cardiovascular disorders, highlighting its potential as a therapeutic target. By facilitating the detection and analysis of MMP23A protein levels, this antibody enables researchers to delve deeper into the molecular mechanisms underlying these conditions and develop targeted interventions for improved patient outcomes.
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20030(MMP23B Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane 1-3: PC3 cells, hela cells, A549 cells, Primary antibody: PACO20030(MMP23B Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20030(MMP23B Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene (MMP23B) encodes a member of the matrix metalloproteinase (MMP) family, and it is part of a duplicated region of chromosome 1p36.3. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. This gene belongs to the more telomeric copy of the duplicated region.
Synonyms:
matrix metallopeptidase 23B
UniProt Protein Function:
MMP23B: Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum. Belongs to the peptidase M10A family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Membrane protein, integral; EC 3.4.24.-; Protease
Chromosomal Location of Human Ortholog: 1p36.3
Cellular Component: proteinaceous extracellular matrix; endoplasmic reticulum membrane; integral to membrane; intracellular
Molecular Function:zinc ion binding; metallopeptidase activity; metalloendopeptidase activity
Biological Process: proteolysis; reproduction
NCBI Summary:
This gene (MMP23B) encodes a member of the matrix metalloproteinase (MMP) family, and it is part of a duplicated region of chromosome 1p36.3. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. This gene belongs to the more telomeric copy of the duplicated region. [provided by RefSeq, Jul 2008]
