Description
MN1 Antibody (PACO01075)
The MN1 Polyclonal Antibody (PACO01075) is a valuable tool for researchers studying MN1, a transcription coactivator involved in hematopoietic development and leukemia. This antibody, produced in rabbits, exhibits high reactivity with human samples and is optimized for Western blot applications. By binding specifically to the MN1 protein, researchers can accurately detect and analyze its expression in various cell types, making it an essential component for studies in hematology and cancer research.
MN1 is a critical player in transcriptional regulation and is known to be dysregulated in leukemia, where it contributes to abnormal cell proliferation and differentiation. Understanding the role of MN1 in these processes is key to developing targeted therapies for leukemia and other hematologic disorders. The MN1 Polyclonal Antibody is a reliable tool for researchers aiming to unravel the complex mechanisms underlying MN1 function and its implications in disease pathology.
| Antibody Name: | MN1 Antibody |
| Antibody SKU: | PACO01075 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | WB:1:500-1:2000 |
| Species Reactivity: | Human |
| Immunogen: | synthesized peptide derived from the Internal region of human MN1. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | MN1; Probable tumor suppressor protein MN1 |
| UniProt Protein Function: | MN1: May play a role in tumor suppression. A chromosomal aberration involving MN1 may be a cause of acute myeloid leukemia (AML). Translocation t(12;22)(p13;q11) with TEL. Defects in MN1 involved in the development of meningiomas, slowly growing benign tumors derived from the arachnoidal cap cells of the leptomeninges, the soft coverings of the brain and spinal cord. Meningiomas are believed to be the most common primary tumors of the central nervous system in man. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; Nuclear receptor co-regulator; Tumor suppressor Chromosomal Location of Human Ortholog: 22q12.1 Disease: Meningioma, Familial, Susceptibility To |
| NCBI Summary: | Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4;22) in a meningioma, and its inactivation may contribute to meningioma 32 pathogenesis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q10571 |
| NCBI GenInfo Identifier: | 215274133 |
| NCBI Gene ID: | 4330 |
| NCBI Accession: | Q10571.3 |
| UniProt Secondary Accession: | Q10571,A9Z1V9, |
| UniProt Related Accession: | Q10571 |
| Molecular Weight: | 136,001 Da |
| NCBI Full Name: | Transcriptional activator MN1 |
| NCBI Synonym Full Names: | MN1 proto-oncogene, transcriptional regulator |
| NCBI Official Symbol: | MN1Â Â |
| NCBI Official Synonym Symbols: | MGCR; MGCR1; MGCR1-PEN; dJ353E16.2Â Â |
| NCBI Protein Information: | transcriptional activator MN1 |
| UniProt Protein Name: | Transcriptional activator MN1 |
| UniProt Synonym Protein Names: | Probable tumor suppressor protein MN1Curated |
| Protein Family: | Transcriptional activator |
| UniProt Gene Name: | MN1Â Â |
| UniProt Entry Name: | MN1_HUMAN |
