Description
MOB1B Antibody (PACO18609)
The MOB1B Polyclonal Antibody (PAC018609) is a specialized tool for researchers studying MOB1B, a protein involved in cell division and growth regulation. This antibody, produced in rabbits, is highly specific for detecting MOB1B in human samples and has been validated for use in Western blot applications. By binding to MOB1B, this antibody allows for accurate detection and analysis of the protein in various cell types, making it a valuable asset for studies in cell biology and cancer research.
MOB1B is a key player in the Hippo signaling pathway, which regulates cell proliferation and organ size. Dysregulation of this pathway has been linked to various types of cancer, making MOB1B a potential therapeutic target. Understanding the function of MOB1B is essential for developing new treatments that target this pathway and could lead to innovative cancer therapies in the future.
| Antibody Name: | MOB1B Antibody (PACO18609) |
| Antibody SKU: | PACO18609 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human MOB1B |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Jurkat cells, K562 cells, mouse testis tissue, Primary antibody: PACO18609(MOB1B Antibody) at dilution 1/225, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
| Background: | The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. |
| Synonyms: | MOB kinase activator 1B |
| UniProt Protein Function: | MOB1B: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. Binds STK38L. Interacts with LATS1 and LATS2. Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver. Belongs to the MOB1/phocein family. |
| UniProt Protein Details: | Protein type:Protein kinase, regulatory subunit; Activator Chromosomal Location of Human Ortholog: 4q13.3 Cellular Component: cytoplasm; cytosol; nucleus Molecular Function:kinase activator activity; kinase binding; protein binding Biological Process: regulation of protein amino acid autophosphorylation |
| NCBI Summary: | The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] |
| UniProt Code: | Q7L9L4 |
| NCBI GenInfo Identifier: | 56749324 |
| NCBI Gene ID: | 92597 |
| NCBI Accession: | Q7L9L4.3 |
| UniProt Secondary Accession: | Q7L9L4,Q8IY23, B2R8U6, B4DRY3, |
| UniProt Related Accession: | Q7L9L4 |
| Molecular Weight: | 25,499 Da |
| NCBI Full Name: | MOB kinase activator 1B |
| NCBI Synonym Full Names: | MOB kinase activator 1B |
| NCBI Official Symbol: | MOB1BÂ Â |
| NCBI Official Synonym Symbols: | MATS2; MOB4A; MOBKL1AÂ Â |
| NCBI Protein Information: | MOB kinase activator 1B |
| UniProt Protein Name: | MOB kinase activator 1B |
| UniProt Synonym Protein Names: | Mob1 homolog 1A; Mob1A; Mob1B; Mps one binder kinase activator-like 1A |
| Protein Family: | MOB kinase activator |
| UniProt Gene Name: | MOB1BÂ Â |
| UniProt Entry Name: | MOB1B_HUMAN |
