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GenieFluor 647 Anti-Mouse CD103 Antibody [M290] (AGEL1152)

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SKU AGEL1152
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Mouse
Host Species Rat
Isotype IgG2a,k
Clone M290
Conjugation AF 647
€192 - €532
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Description

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GenieFluor 647 Anti-Mouse CD103 Antibody [M290]

The Mouse CD103 Monoclonal Antibody (AF647 Conjugated, M290) is a highly specific antibody designed for research involving the CD103 protein, a cell surface marker widely used to identify tissue-resident immune cells such as dendritic cells and T cells. This antibody, conjugated to Alexa Fluor 647, offers superior sensitivity and fluorescence intensity for flow cytometry and immunofluorescence applications.CD103, also known as αE integrin, plays a crucial role in the retention and function of immune cells within tissues, particularly in the gut and skin. By targeting CD103, researchers can better understand the behavior and function of tissue-resident immune cells in various physiological and pathological conditions.

This antibody is particularly valuable for studying immune responses in the context of infection, inflammation, and autoimmunity, providing insights that can potentially lead to the development of novel therapeutic strategies.With its validated specificity and excellent performance in various experimental techniques, the Mouse CD103 Monoclonal Antibody (AF647 Conjugated, M290) is an essential tool for researchers in immunology, infectious diseases, and cancer biology seeking to unravel the complexities of tissue-specific immune responses.

Product Title:GenieFluor 647 Anti-Mouse CD103 Antibody [M290]
SKU:AGEL1152
Size:50 Tests, 100 Tests, 200 Tests
Clone No:M290
Synonyms:Integrin alpha-E;Itgae;Integrin alpha M290;CD103;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:Genie Fluor 647 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:Genie Fluor647
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q60677
Gene ID:16407
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.

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