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GenieFluor 488 Anti-Mouse CD11a Antibody [FD441.8] (AGEL0838)

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SKU AGEL0838
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Mouse
Host Species Rat
Isotype IgG2a,k
Clone FD441.8
Conjugation AF 488
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Description

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GenieFluor 488 Anti-Mouse CD11a Antibody [FD441.8]

The Mouse CD11a Monoclonal Antibody (AF488 Conjugated) (FD441.8) is a powerful tool for researchers investigating CD11a, an integral membrane protein belonging to the integrin family involved in cell adhesion and migration processes. This antibody, derived from mouse monoclonal sources and conjugated with AF488 for easy fluorescent detection, exhibits high specificity and sensitivity in binding to CD11a proteins in mouse samples.CD11a is a crucial component of lymphocyte function-associated antigen 1 (LFA-1), a cell surface receptor essential for T cell activation, adhesion to antigen-presenting cells, and migration across endothelial barriers. By targeting CD11a, researchers can study immune cell interactions, inflammatory responses, and immune cell trafficking in various experimental models.

With its fluorescent conjugation, this antibody is particularly suitable for flow cytometry, immunofluorescence microscopy, and other fluorescent detection methods, enabling precise visualization and analysis of CD11a expression and localization in different cell types and tissues. It is a valuable tool in immunology, inflammation, and autoimmune disease research, providing insights into the mechanisms underlying immune cell function and potential therapeutic targets for immune-related disorders.For researchers investigating immune responses, cell adhesion, and migration processes mediated by integrins, the Mouse CD11a Monoclonal Antibody (AF488 Conjugated) (FD441.8) offers a reliable and efficient solution for detecting and studying CD11a protein expression and activity.

Product Title:GenieFluor 488 Anti-Mouse CD11a Antibody [FD441.8]
SKU:AGEL0838
Size:25µg, 100µg
Clone No:FD441.8
Synonyms:Integrin alpha-L;Itgal;CD11 antigen-like family member A;LFA-1A;Lymphocyte antigen 15;Ly-15;CD11a;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:Genie Fluor 488 Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:Genie Fluor488
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P24063
Gene ID:16408
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD11a is a 180 kD glycoprotein, also known as αL integrin, LFA-1 α, Ly-15, or Ly-21. It is a member of the integrin family, primarily expressed on lymphocytes, monocytes/macrophages, and granulocytes. In association with CD18, the CD11a/CD18 complex forms LFA-1. CD11a plays an important role in intercellular adhesion and costimulation by binding its ligands, ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50).

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