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GenieFluor 488 Anti-Mouse CD122 Antibody [5H4] (AGEL0806)

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SKU AGEL0806
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Mouse
Host Species Rat
Isotype IgG2a,k
Clone 5H4
Conjugation AF 488
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Description

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GenieFluor 488 Anti-Mouse CD122 Antibody [5H4]

The Mouse CD122 Monoclonal Antibody (AF488 Conjugated 5H4-AGEL0806) offered by Assaygenie is a vital tool for researchers studying CD122, a cell surface protein crucial for immune system function and regulating immune responses. This monoclonal antibody, conjugated with AF488 for fluorescent detection, is specifically designed for use in various applications, including flow cytometry, immunofluorescence, and immunohistochemistry.CD122, also known as the IL-2 receptor beta chain, is a key component in the IL-2 receptor complex and plays a pivotal role in immune cell activation and proliferation.

The AF488-conjugated 5H4 antibody enables precise and reliable detection of CD122 in mouse samples, facilitating detailed analysis of immune cell populations and responses.By using this monoclonal antibody, researchers can gain valuable insights into the functions and interactions of CD122 in immune system regulation, inflammatory processes, and potential therapeutic targets. Its versatility and specificity make it an indispensable tool for studies in immunology, cancer biology, and other fields requiring precise monitoring of CD122 expression and activity in mouse models.

Product Title:GenieFluor 488 Anti-Mouse CD122 Antibody [5H4]
SKU:AGEL0806
Size:25µg, 100µg
Clone No:5H4
Synonyms:Interleukin-2 receptor subunit beta;Il2rb;IL-2 receptor subunit beta; IL-2R subunit beta;IL-2RB;High affinity IL-2 receptor subunit beta;p70-75;CD122;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:Genie Fluor 488 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:Genie Fluor488
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P16297
Gene ID:16185
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD122 is a 70-75 kD IL-2 receptor β chain also known as IL-2Rβ, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rβ chain can combine with either the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rα subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation. The 5H4 antibody does not block IL-2 binding to the IL-2 receptor. CD122 is expressed on murine, but not human, CD8+ Tregs involved in the maintenance of T cell homeostasis.

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