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GenieFluor 647 Anti-Mouse CD122 Antibody [5H4] (AGEL0798)

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SKU AGEL0798
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Mouse
Host Species Rat
Isotype IgG2a,k
Clone 5H4
Conjugation AF 647
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Description

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GenieFluor 647 Anti-Mouse CD122 Antibody [5H4]

The Mouse CD122 Monoclonal Antibody (AF647 Conjugated) 5H4 (AGEL0798) is a potent tool for researchers studying immune responses and cell signaling pathways in mice. This monoclonal antibody, labeled with AF647 for fluorescent detection, specifically targets the CD122 protein, which plays a crucial role in immune system function and T cell activation.CD122, also known as the interleukin-2 receptor beta chain, is essential for the proper functioning of the immune system by mediating the response to interleukin-2 (IL-2), a key cytokine involved in T cell proliferation and differentiation. The 5H4 antibody is designed to specifically recognize and bind to CD122, allowing for accurate detection and analysis in various experimental settings.

Researchers in immunology, cancer biology, and autoimmune disease studies can benefit from the use of this antibody to investigate the role of CD122 in immune cell activation, proliferation, and differentiation. By understanding the mechanisms involving CD122, scientists can gain insights into immune responses in various disease states and potentially develop new therapeutic strategies targeting this pathway.Overall, the Mouse CD122 Monoclonal Antibody (AF647 Conjugated) 5H4 (AGEL0798) is a valuable tool for research projects focused on dissecting immune responses, cytokine signaling, and T cell function in mouse models.

Product Title:GenieFluor 647 Anti-Mouse CD122 Antibody [5H4]
SKU:AGEL0798
Size:50 Tests, 100 Tests, 200 Tests
Clone No:5H4
Synonyms:Interleukin-2 receptor subunit beta;Il2rb;IL-2 receptor subunit beta; IL-2R subunit beta;IL-2RB;High affinity IL-2 receptor subunit beta;p70-75;CD122;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:Genie Fluor 647 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:Genie Fluor647
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P16297
Gene ID:16185
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD122 is a 70-75 kD IL-2 receptor β chain also known as IL-2Rβ, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rβ chain can combine with either the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rα subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation. The 5H4 antibody does not block IL-2 binding to the IL-2 receptor. CD122 is expressed on murine, but not human, CD8+ Tregs involved in the maintenance of T cell homeostasis.

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