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GenieFluor 647 Anti-Mouse CD122 Antibody [5H4] (AGEL0807)

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SKU AGEL0807
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Mouse
Host Species Rat
Isotype IgG2a,k
Clone 5H4
Conjugation AF 647
€125 - €325
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Description

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GenieFluor 647 Anti-Mouse CD122 Antibody [5H4]

The Mouse CD122 Monoclonal Antibody (AF647 Conjugated, 5H4, AGL0807) is a cutting-edge tool for researchers investigating CD122, a critical cell surface receptor involved in immune system regulation and T-cell function. This monoclonal antibody, conjugated with AF647 for fluorescence detection, offers high specificity and sensitivity in detecting mouse CD122 in various experimental settings.CD122, also known as the IL-2 receptor beta chain, plays a pivotal role in controlling immune responses, particularly in T-cell activation and proliferation.

By targeting CD122, researchers can gain insights into the mechanisms governing immune system function, making the antibody indispensable for studies in immunology, vaccine development, and autoimmune disease research.With its advanced conjugation technology and exceptional performance characteristics, the Mouse CD122 Monoclonal Antibody (AF647 Conjugated, 5H4, AGL0807) is a valuable asset for scientists seeking to unravel the complexities of immune regulation and develop innovative therapeutic strategies.

Product Title:GenieFluor 647 Anti-Mouse CD122 Antibody [5H4]
SKU:AGEL0807
Size:25µg, 100µg
Clone No:5H4
Synonyms:Interleukin-2 receptor subunit beta;Il2rb;IL-2 receptor subunit beta; IL-2R subunit beta;IL-2RB;High affinity IL-2 receptor subunit beta;p70-75;CD122;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:Genie Fluor 647 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:Genie Fluor647
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P16297
Gene ID:16185
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD122 is a 70-75 kD IL-2 receptor β chain also known as IL-2Rβ, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rβ chain can combine with either the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rα subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation. The 5H4 antibody does not block IL-2 binding to the IL-2 receptor. CD122 is expressed on murine, but not human, CD8+ Tregs involved in the maintenance of T cell homeostasis.

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