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PE/Cyanine5.5 Anti-Mouse CD122 Antibody [5H4] (AGEL0796)

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SKU AGEL0796
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Mouse
Applications FC
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Description

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PE/Cyanine5.5 Anti-Mouse CD122 Antibody [5H4]

The Mouse CD122 Monoclonal Antibody PE-Cyanine5.5 Conjugated (5H4) is a powerful tool designed for research in the field of immunology. This antibody specifically targets CD122, a cell surface receptor essential for the function of natural killer cells and T cells. By binding to CD122, the antibody enables precise detection and analysis of this important protein in various cell types.CD122, also known as the IL-2 receptor beta chain, plays a crucial role in the immune system by mediating the response of immune cells to interleukin-2 (IL-2), a key cytokine involved in immune regulation.

Understanding the expression and function of CD122 is vital for studying immune responses, autoimmune diseases, and cancer immunotherapy. The Mouse CD122 Monoclonal Antibody PE-Cyanine5.5 Conjugated (5H4) offers high specificity and sensitivity for studying CD122 expression, making it an invaluable asset for researchers delving into the intricate mechanisms of immune response modulation and therapeutic development.

Product Title:PE/Cyanine5.5 Anti-Mouse CD122 Antibody [5H4]
SKU:AGEL0796
Size:50 Tests, 100 Tests, 200 Tests
Clone No:5H4
Synonyms:Interleukin-2 receptor subunit beta;Il2rb;IL-2 receptor subunit beta; IL-2R subunit beta;IL-2RB;High affinity IL-2 receptor subunit beta;p70-75;CD122;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE/Cyanine5.5 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE/Cyanine 5.5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P16297
Gene ID:16185
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD122 is a 70-75 kD IL-2 receptor β chain also known as IL-2Rβ, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rβ chain can combine with either the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rα subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation. The 5H4 antibody does not block IL-2 binding to the IL-2 receptor. CD122 is expressed on murine, but not human, CD8+ Tregs involved in the maintenance of T cell homeostasis.

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