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PE/Cyanine5 Anti-Mouse CD127/IL-7RA Antibody [A7R34] (AGEL0749)

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SKU AGEL0749
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Mouse
Host Species Rat
Isotype IgG2a,k
Clone A7R34
Conjugation PE/Cy5
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Description

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PE/Cyanine5 Anti-Mouse CD127/IL-7RA Antibody [A7R34]

The Mouse CD127 (IL-7RA) Monoclonal Antibody PE-Cyanine5 Conjugated (A7R34) is a powerful tool for immunological research involving the CD127 receptor, also known as IL-7RA. This monoclonal antibody, conjugated with PE-Cyanine5, is specifically designed for flow cytometry applications, enabling precise detection and analysis of CD127 expression on immune cells.CD127, a key component of the interleukin-7 receptor complex, plays a crucial role in regulating immune cell development, survival, and function. Its expression is essential for the maintenance of T cell homeostasis and response to IL-7 signaling. The A7R34 antibody binds specifically to CD127, allowing researchers to investigate the distribution and levels of this receptor on different immune cell subsets.

This antibody is ideal for studies focused on T cell biology, lymphocyte development, and immune system function. By targeting CD127, researchers can gain valuable insights into the mechanisms underlying immune responses, immune cell differentiation, and the pathogenesis of various diseases. The Mouse CD127 (IL-7RA) Monoclonal Antibody PE-Cyanine5 Conjugated (A7R34) is a reliable reagent for advancing our understanding of immune regulation and may pave the way for the development of novel immunotherapies and treatment strategies.

Product Title:PE/Cyanine5 Anti-Mouse CD127/IL-7RA Antibody [A7R34]
SKU:AGEL0749
Size:25µg, 100µg
Clone No:A7R34
Synonyms:Interleukin-7 receptor subunit alpha;Il7r;IL-7 receptor subunit alpha;IL-7R subunit alpha;IL-7R-alpha;IL-7RA;CD127;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE/Cyanine5 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE/Cyanine 5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P16872
Gene ID:16197
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD127 is a 60-90 kD type I transmembrane glycoprotein also known as IL-7 receptor α chain or IL-7Rα. It forms a heterodimer with the common γ chain (γc or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be an useful marker for identifying memory and effector T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cells proliferation and development.

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