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GenieFluor 488 Anti-Mouse CD161/NK1.1 Antibody [PK136] (AGEL0492)

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SKU AGEL0492
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Mouse
Host Species Mouse
Isotype IgG2a,k
Clone PK136
Conjugation AF 488
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Description

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GenieFluor 488 Anti-Mouse CD161/NK1.1 Antibody [PK136]

The Mouse CD161/NK1.1 Monoclonal Antibody (AF488 Conjugated, Clone PK136) is a versatile tool for studying immune cells expressing the CD161 and NK1.1 surface markers. This antibody, conjugated to AF488 for fluorescence-based applications, specifically targets the PK136 epitope, allowing for precise detection and analysis in flow cytometry, immunofluorescence, and other experimental techniques.CD161 and NK1.1 are markers commonly found on natural killer (NK) cells, innate lymphoid cells, and other immune cell subsets. By using this monoclonal antibody, researchers can explore the distribution, function, and interactions of these cells in various tissues and experimental models.

The AF488 conjugation provides enhanced sensitivity and signal-to-noise ratios, enabling robust and reliable data acquisition.Understanding the role of CD161 and NK1.1-expressing cells is important in immunology research, including studies on host defense, immune surveillance, and inflammatory responses. This antibody offers researchers a valuable tool to dissect the complex functions of these immune cell populations in health and disease, including infectious diseases, cancer immunology, and autoimmune conditions.

Product Title:GenieFluor 488 Anti-Mouse CD161/NK1.1 Antibody [PK136]
SKU:AGEL0492
Size:25µg, 100µg
Clone No:PK136
Synonyms:Killer cell lectin-like receptor subfamily B member 1C;Klrb1c;CD161 antigen-like family member C;Ly-55c;CD161/NK1.1;NKR-P1.9;NKR-P1C;NKR-P1 40;CD161c;
Host Species:Mouse
Reactivity:Mouse
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:Genie Fluor 488 Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:Genie Fluor488
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P27814 P27812 Q99JB4
Gene ID:17059
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:NK-1.1 surface antigen, also known as CD161b/CD161c and Ly-55, is encoded by the NKR-P1B/NKR-P1C gene. It is expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN-γ production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers.

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