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PE/Cyanine5 Anti-Mouse CD161/NK1.1 Antibody [PK136] (AGEL0488)

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SKU AGEL0488
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Mouse
Host Species Mouse
Isotype IgG2a,k
Clone PK136
Conjugation PE/Cy5
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Description

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PE/Cyanine5 Anti-Mouse CD161/NK1.1 Antibody [PK136]

The Mouse CD161 (NK1.1) Monoclonal Antibody PE-Cyanine5 Conjugated (PK136) (AGEL0488) is a powerful tool for studying natural killer (NK) cells and innate immunity. This monoclonal antibody specifically targets the CD161 marker, also known as NK1.1, which is commonly expressed on NK cells and some T cell subsets in mice. By conjugating with PE-Cyanine5, this antibody allows for easy detection and analysis of CD161-expressing cells using flow cytometry.NK cells are pivotal players in the innate immune system, contributing to host defense against infections and surveillance for abnormal cells, including tumor cells. The expression of CD161 is a key identifier of NK cells in mice and plays a role in their activation and function.

The PK136 antibody provides researchers with a reliable tool to investigate the role of NK cells in various immunological processes, such as infection, inflammation, and tumor immunity.With its high specificity and conjugation with PE-Cyanine5, the Mouse CD161 (NK1.1) Monoclonal Antibody PK136 is an essential reagent for immunologists and researchers studying mouse immune responses. Its application extends to a wide range of studies, including immunology, infectious diseases, cancer research, and autoimmune disorders. By targeting CD161, this antibody facilitates precise identification and characterization of NK cells, contributing to advancements in our understanding of innate immunity and immune-mediated diseases.

Product Title:PE/Cyanine5 Anti-Mouse CD161/NK1.1 Antibody [PK136]
SKU:AGEL0488
Size:25µg, 100µg
Clone No:PK136
Synonyms:Killer cell lectin-like receptor subfamily B member 1C;Klrb1c;CD161 antigen-like family member C;Ly-55c;CD161/NK1.1;NKR-P1.9;NKR-P1C;NKR-P1 40;CD161c;
Host Species:Mouse
Reactivity:Mouse
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:PE/Cyanine5 Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:PE/Cyanine 5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P27814 P27812 Q99JB4
Gene ID:17059
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:NK-1.1 surface antigen, also known as CD161b/CD161c and Ly-55, is encoded by the NKR-P1B/NKR-P1C gene. It is expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN-γ production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers.

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