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GenieFluor 647 Anti-Mouse CD279/PD-1 Antibody [29F.1A12] (AGEL1631)

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SKU AGEL1631
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Mouse
Host Species Rat
Isotype IgG2a,k
Clone 29F.1A12
Conjugation AF 647
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Description

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GenieFluor 647 Anti-Mouse CD279/PD-1 Antibody [29F.1A12]

The Mouse CD279 (PD-1) Monoclonal Antibody (AF647 Conjugated) is a powerful tool for researchers studying immune checkpoint molecules and their role in immune regulation. This antibody, designated 29F.1A12 (AGEL1631), is specifically designed to target the CD279 (PD-1) protein, a key immune checkpoint receptor involved in regulating T-cell activation and tolerance.By conjugating with AF647, this monoclonal antibody allows for sensitive detection and visualization of CD279 (PD-1) in various experimental applications, such as flow cytometry and immunofluorescence. Its high specificity and affinity make it an ideal choice for studying the expression and function of CD279 (PD-1) in immune cells, particularly in the context of cancer immunotherapy and autoimmune diseases.

The CD279 (PD-1) pathway has emerged as a promising target for developing novel immunotherapies that enhance anti-tumor immune responses. Research using this antibody can provide valuable insights into the mechanisms underlying immune evasion and potential strategies to overcome immune suppression in the tumor microenvironment. Overall, the Mouse CD279 (PD-1) Monoclonal Antibody (AF647 Conjugated) offers researchers a reliable tool to advance their studies in immunology, oncology, and immune regulation.

Product Title:GenieFluor 647 Anti-Mouse CD279/PD-1 Antibody [29F.1A12]
SKU:AGEL1631
Size:50 Tests, 100 Tests, 200 Tests
Clone No:29F.1A12
Synonyms:PD-1; Programmed Death-1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:Genie Fluor 647 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:Genie Fluor647
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q02242
Gene ID:18566
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

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