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GenieFluor 647 Anti-Mouse CD279/PD-1 Antibody [29F.1A12] (AGEL1636)

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SKU AGEL1636
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Mouse
Host Species Rat
Isotype IgG2a,k
Clone 29F.1A12
Conjugation AF 647
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Description

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GenieFluor 647 Anti-Mouse CD279/PD-1 Antibody [29F.1A12]

The Mouse CD279 (PD-1) Monoclonal Antibody (AF647 Conjugated, 29F.1A12) is a powerful tool for research in immunology and cancer biology. This antibody, available from AssayGenie, specifically targets the PD-1 protein, a key immune checkpoint receptor with essential roles in regulating immune responses.PD-1, also known as Programmed cell death protein 1, is a critical immune checkpoint receptor that plays a key role in regulating immune responses and maintaining self-tolerance. By binding to its ligands, PD-1 negatively regulates T cell activation and helps prevent overactive immune responses that can lead to autoimmunity or chronic inflammation.The AF647-conjugated 29F.1A12 monoclonal antibody offers high specificity and sensitivity for detecting PD-1 in various cell types and tissue samples.

Its conjugation with AF647 allows for easy visualization and analysis of PD-1 expression using fluorescence-based techniques, such as flow cytometry and immunofluorescence microscopy.Researchers studying immune checkpoint pathways, tumor immunology, and immunotherapy will find the Mouse CD279 (PD-1) Monoclonal Antibody (AF647 Conjugated, 29F.1A12) to be a valuable tool for investigating the role of PD-1 in immune regulation and its potential as a therapeutic target in cancer. Trust AssayGenie for high-quality antibodies that deliver reliable results for your research needs.

Product Title:GenieFluor 647 Anti-Mouse CD279/PD-1 Antibody [29F.1A12]
SKU:AGEL1636
Size:25µg, 100µg
Clone No:29F.1A12
Synonyms:PD-1; Programmed Death-1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:Genie Fluor 647 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:Genie Fluor647
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q02242
Gene ID:18566
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

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