The Mouse CD28 Monoclonal Antibody (AF488 Conjugated, 37-51) is a valuable tool for research involving CD28, a crucial T-cell co-stimulatory molecule involved in immune response regulation. This monoclonal antibody, conjugated with AF488 for enhanced detection in fluorescence-based assays, is specifically designed for experiments in immunology, cell biology, and related fields.CD28 is a key player in T-cell activation and is essential for initiating and sustaining immune responses. By targeting CD28, researchers can gain insights into T-cell activation mechanisms, immune system modulation, and potential therapeutic targets for immune-related disorders. This antibody, generated in mice, demonstrates high specificity and sensitivity for detecting CD28 expression in mouse samples, making it suitable for a wide range of experimental applications such as flow cytometry, immunofluorescence, and immunohistochemistry.
Overall, the Mouse CD28 Monoclonal Antibody (AF488 Conjugated, 37-51) offers researchers a reliable tool to advance their studies in immunology, vaccine development, and autoimmunity research. Its ability to detect and analyze CD28 expression in mouse samples with high precision makes it an indispensable resource for unraveling the complexities of immune responses and developing targeted interventions for immune-related diseases.
Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:
Swissprot:
P31041
Gene ID:
12487
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD28 is a 44 kD glycoprotein, also known as Tp44 or T44. It is a member of the Ig superfamily, expressed on thymocytes, most peripheral T cells, and NK cells. In association with CD80 (B7-1) and CD86 (B7-2), CD28 acts as the second signal for T and NK cell activation and proliferation. The 37.51 antibody has been reported to augment in vitro T cell proliferation and cytokine production, and promote CTL development.
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