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PE Anti-Mouse CD3ε Antibody [145-2C11] (AGEL0376)

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SKU AGEL0376
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Mouse
Host Species Hamster
Isotype IgG
Clone 145-2C11
Conjugation PE
Applications FC
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Description

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PE Anti-Mouse CD3ε Antibody [145-2C11]

The Mouse CD3 Epsilon Monoclonal Antibody PE-Conjugated (145-2C11, AGEL0376) is a powerful tool for researchers studying immune responses and T cell activation in mouse models. This monoclonal antibody specifically targets the CD3 epsilon chain, a critical component of the T cell receptor complex essential for T cell function.With its PE conjugation, this antibody enables easy and reliable flow cytometry analysis of CD3 epsilon expression on T cells. It allows researchers to accurately quantify and isolate T cell populations in various tissues and experimental conditions. The high specificity and sensitivity of this antibody make it a valuable asset for immunology research, particularly in studies of T cell signaling, activation, and differentiation.

The CD3 epsilon chain is central to T cell development and function, playing a key role in antigen recognition and T cell receptor signaling. By targeting this crucial molecule, researchers can gain insights into immune response dynamics, T cell behavior, and the underlying mechanisms of immune-related diseases. Utilizing the Mouse CD3 Epsilon Monoclonal Antibody PE-Conjugated (145-2C11, AGEL0376) opens up new possibilities for investigating T cell biology and advancing our understanding of immune system functionality in mouse models.

Product Title:PE Anti-Mouse CD3ε Antibody [145-2C11]
SKU:AGEL0376
Size:50 Tests, 100 Tests, 200 Tests
Clone No:145-2C11
Synonyms:T-cell surface glycoprotein CD3 epsilon chain;CD3E;T-cell surface antigen T3/Leu-4 epsilon chain;CD3e;CD3E;T3E;
Host Species:Armenian Hamster
Reactivity:Mouse
Application:FCM
Isotype:Armenian Hamster IgG
Isotype Control:PE Armenian Hamster IgG Isotype Control[PIP]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P22646
Gene ID:12501
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD3ε is a 20 kD transmembrane protein, also known as CD3 or T3. It is a member of the Ig superfamily and primarily expressed on T cells, NK-T cells, and at different levels on thymocytes during T cell differentiation. CD3ε forms a TCR complex by associating with the CD3δ, γ and ζ chains, as well as the TCR α/β or γ/δ chains. CD3 plays a critical role in TCR signal transduction, T cell activation, and antigen recognition by binding the peptide/MHC antigen complex.

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