Description
| Product Name: | Mouse CD4 monoclonal antibody (FITC) |
| Product Code: | AGIM0265 |
| Size: | 500 µL |
| Reactivity: | Mouse |
| Clone: | GK1.5 |
| Applications: | Flow Cytometry |
| Conjugate: | FITC |
| Isotype: | IgG2b |
| Host Species: | Rat |
| Storage: | Store at 4°C. Avoid prolonged exposure to light. |
| Uniprot: | P06332 |
| UniProt Protein Function: | CD4: Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI- CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins. Interacts with PTK2/FAK1; this interaction requires the presence of HIV-1 gp120. |
| UniProt Protein Details: | Protein type:Cell surface; Membrane protein, integral Chromosomal Location of Human Ortholog: 6 F2|6 59.17 cM Cellular Component: cell surface; endoplasmic reticulum lumen; endoplasmic reticulum membrane; external side of plasma membrane; lipid raft; plasma membrane Molecular Function:enzyme binding; glycoprotein binding; immunoglobulin binding; MHC class II protein binding; protein homodimerization activity; protein kinase binding; zinc ion binding Biological Process: cell surface receptor linked signal transduction; cytokine production; defense response to Gram-negative bacterium; induction by virus of cell-cell fusion in host; maintenance of cellular protein localization; positive regulation of calcium-mediated signaling; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase activity; positive regulation of T cell activation; positive regulation of T cell proliferation; regulation of T cell activation; T cell activation; T cell differentiation; T cell selection |
| UniProt Code: | P06332 |
| NCBI GenInfo Identifier: | 116015 |
| NCBI Gene ID: | 12504 |
| NCBI Accession: | P06332.1 |
| UniProt Related Accession: | P06332 |
| Molecular Weight: | 24,473 Da |
| NCBI Full Name: | T-cell surface glycoprotein CD4 |
| NCBI Synonym Full Names: | CD4 antigen |
| NCBI Official Symbol: | Cd4Â Â |
| NCBI Official Synonym Symbols: | L3T4; Ly-4Â Â |
| NCBI Protein Information: | T-cell surface glycoprotein CD4 |
| UniProt Protein Name: | T-cell surface glycoprotein CD4 |
| UniProt Synonym Protein Names: | T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; CD_antigen: CD4 |
| Protein Family: | CD40 ligand |
| UniProt Gene Name: | Cd4Â Â |
