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APC Anti-Mouse CD40 Antibody [FGK4.5/FGK45] (AGEL0784)

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SKU AGEL0784
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Mouse
Host Species Rat
Isotype IgG2a,k
Clone FGK4.5/FGK45
Conjugation APC
€105 - €285
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Description

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APC Anti-Mouse CD40 Antibody [FGK4.5/FGK45]

The Mouse CD40 Monoclonal Antibody (APC Conjugated) FGK4.5 (FGK4.5-AGEL0784) is a specialized reagent designed for research applications involving the CD40 protein, a cell surface receptor crucial for immune system activation. This monoclonal antibody, characterized by its specificity and high affinity, is conjugated with APC for fluorescence-based detection methods, providing a valuable tool for flow cytometry and immunofluorescence analyses.CD40, a member of the TNF receptor superfamily, is involved in various immune functions, including B cell activation, antibody production, and antigen presentation.

Its role in regulating immune responses and inflammation underscores its importance in studies related to immunology, infectious diseases, and autoimmune disorders. Utilizing the FGK4.5 monoclonal antibody allows for precise detection and characterization of CD40 expression in different cell types, making it an essential reagent for investigating immune system interactions and developing targeted therapeutic strategies.

Product Title:APC Anti-Mouse CD40 Antibody [FGK4.5/FGK45]
SKU:AGEL0784
Size:25µg, 100µg
Clone No:FGK4.5/FGK45
Synonyms:Tumor necrosis factor receptor superfamily member 5;Cd40;B-cell surface antigen CD40;Bp50;CD40L receptor;CD40;Tnfrsf5;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:APC Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P27512
Gene ID:21939
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD40 is a 48 kD type I transmembrane glycoprotein also known as Bp50. It is a member of the tumor necrosis factor receptor (TNFR) superfamily and is expressed on B cells, basal epithelial cells, macrophages, follicular dendritic cells, endothelial cells, and a subset of CD34+ hematopoietic progenitors. CD40 regulates B cell development/maturation, Ig isotype switching and, in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with its ligand CD154 (gp39), which is expressed on activated T cells, is important in costimulation and immune regulation.

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