Description
system_update_altDatasheet
| Product Name: | Mouse CD45 monoclonal antibody (APC) |
| Product Code: | AGIM0555 |
| Size: | 100 µL |
| Reactivity: | Mouse |
| Clone: | IBL-5/25 |
| Applications: | Flow Cytometry |
| Conjugate: | APC |
| Isotype: | IgG1/?? |
| Host Species: | Rat |
| Storage: | Store at 4°C. Avoid prolonged exposure to light. |
| Uniprot: | Q14761 |
| Background: | CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. |
| UniProt Protein Function: | PTPRCAP: Interacts with CD45/PTPRC. |
| UniProt Protein Details: | Protein type:Cell surface; Membrane protein, integral Chromosomal Location of Human Ortholog: 11q13.2 Cellular Component: plasma membrane Biological Process: defense response |
| NCBI Summary: | The protein encoded by this gene was identified as a transmembrane phosphoprotein specifically associated with tyrosine phosphatase PTPRC/CD45, a key regulator of T- and B-lymphocyte activation. The interaction with PTPRC may be required for the stable expression of this protein. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14761 |
| NCBI GenInfo Identifier: | 22001841 |
| NCBI Gene ID: | 5790 |
| NCBI Accession: | Q14761.1 |
| UniProt Secondary Accession: | Q14761,O00643, Q6I9S6, B2R512, |
| UniProt Related Accession: | Q14761 |
| Molecular Weight: | 21kDa |
| NCBI Full Name: | Protein tyrosine phosphatase receptor type C-associated protein |
| NCBI Synonym Full Names: | protein tyrosine phosphatase, receptor type C associated protein |
| NCBI Official Symbol: | PTPRCAPÂ Â |
| NCBI Official Synonym Symbols: | LPAP; CD45-APÂ Â |
| NCBI Protein Information: | protein tyrosine phosphatase receptor type C-associated protein |
| UniProt Protein Name: | Protein tyrosine phosphatase receptor type C-associated protein |
| UniProt Synonym Protein Names: | CD45-associated protein; CD45-AP; Lymphocyte phosphatase-associated phosphoprotein |
| Protein Family: | Protein tyrosine phosphatase receptor type C-associated protein |
| UniProt Gene Name: | PTPRCAPÂ Â |
![APC Anti-Mouse CD45 Antibody [30-F11] (AGEL1669)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/images/stencil/590x590/products/237551/618081/apc-anti-mouse-cd45-antibody-30-f11-agel1669__29508.1732237790.jpg?c=2 "APC Anti-Mouse CD45 Antibody [30-F11] (AGEL1669)")