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Biotin Anti-Mouse CD45R/B220 Antibody [RA3.3A 1/6.1] (AGEL0422)

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SKU AGEL0422
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Mouse
Host Species Rat
Isotype IgM
Clone RA3.3A 1/6.1
Conjugation Biotin
Applications FC
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Description

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Biotin Anti-Mouse CD45R/B220 Antibody [RA3.3A 1/6.1]

The Mouse CD45R B220 Monoclonal Antibody (Biotin Conjugated) - RA3-3A1 (6.1) (AGEL0422) offered by Assay Genie is a high-quality research tool specifically designed for studying CD45R B220, a cell surface marker predominantly found on B cells and a subset of T cells in mice. This monoclonal antibody, conjugated with biotin for enhanced detection capabilities, is meticulously validated for various research applications.CD45R B220, also known as B220 or CD45R/B220, is a well-known marker for identifying B cell populations and subsets, aiding in the characterization of B cell development, activation, and differentiation processes.

The expression of CD45R B220 is crucial in immunological studies focusing on B cell biology, immunophenotyping, and immune responses in murine models.This monoclonal antibody, RA3-3A1 (6.1), demonstrates high specificity and sensitivity in recognizing CD45R B220, enabling precise detection and analysis of B cell populations in different tissues and experimental setups. Researchers in immunology, hematology, and vaccine development can greatly benefit from the precise targeting and detection capabilities of this antibody, contributing to advancements in understanding B cell biology and immune system function in mice.

Product Title:Biotin Anti-Mouse CD45R/B220 Antibody [RA3.3A 1/6.1]
SKU:AGEL0422
Size:25µg, 100µg
Clone No:RA3.3A 1/6.1
Synonyms:B220;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgM, κ
Isotype Control:Biotin Rat IgM, κ Isotype Control[RTK2118]
Form:Liquid
Conjugation:Biotin
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Gene ID:19264,5788
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD45R, also known as B220, is an isoform of CD45. It is a member of the protein tyrosine phosphatase (PTP) family with a molecular weight of approximately 180-240 kD. CD45R is expressed on B cells (at all developmental stages from pro-B cells through mature B cells), activated B cells, and subsets of T and NK cells. CD45R (B220) is also expressed on a subset of abnormal T cells involved in the pathogenesis of systemic autoimmunity in MRL-Faslpr and MRL-Fasgld mice. It plays a critical role in TCR and BCR signaling. The primary ligands for CD45 are galectin-1, CD2, CD3, and CD4. CD45R is commonly used as a pan-B cell marker; however, CD19 may be more appropriate for B cell specificity.

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