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GenieFluor 488 Anti-Mouse CD49b Antibody [DX5] (AGEL1453)

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SKU AGEL1453
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Mouse
Host Species Rat
Isotype IgG2a,k
Clone DX5
Conjugation AF 488
€100 - €325
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Description

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GenieFluor 488 Anti-Mouse CD49b Antibody [DX5]

The Mouse CD49b Monoclonal Antibody (AF488 conjugated, clone DX5, Cat# AG-EL1453) from AssayGenie is a highly specific antibody designed for research involving CD49b, a cell surface molecule important in immune response and cell-to-cell interactions. This monoclonal antibody is conjugated with AF488 for convenient fluorescent detection and is validated for various immunological applications.CD49b, also known as integrin alpha-2, plays a critical role in cell adhesion and migration processes, particularly in the immune system. It is involved in regulating leukocyte trafficking and activation, making it an essential target for studies in immunology and inflammation research.

The AF488-conjugated CD49b antibody enables precise detection and visualization of CD49b expression in different cell types, aiding in the understanding of its function in various biological processes.Researchers studying immune responses, cell adhesion, and inflammatory conditions will find the Mouse CD49b Monoclonal Antibody (AF488 conjugated, clone DX5) a valuable tool for their experiments. With its high specificity and fluorescent labeling, this antibody facilitates accurate and reliable detection of CD49b in samples, contributing to advancements in immunological research and potential therapeutic developments.

Product Title:GenieFluor 488 Anti-Mouse CD49b Antibody [DX5]
SKU:AGEL1453
Size:25µg, 100µg
Clone No:DX5
Synonyms:Integrin alpha-2;CD49 antigen-like family member B;Collagen receptor;Platelet membrane glycoprotein Ia;GPIa;VLA-2 subunit alpha;CD49b;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgM, κ
Isotype Control:Genie Fluor 488 Rat IgM, κ Isotype Control[RTK2118]
Form:Liquid
Conjugation:Genie Fluor488
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q62469
Gene ID:16398
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:DX5 antigen has been recently characterized as CD49b. It is a 150 kD integrin α chain also known as α2 integrin, VLA-2 α chain, and integrin α2 chain. CD49b non-covalently associates with CD29 (β1 integrin) to form the CD49b/CD29 complex known as VLA-2, a receptor for collagen and laminin. CD49b is expressed on platelets, the majority of NK cells, NKT cells, and a small subset of CD8+ T cells (this population can be significantly increased following viral infection). DX5 is used for the identification and isolation of NK cells, and is especially useful for identifying NK cells in mice lacking the NK1.1 antigen.

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