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GenieFluor 647 Anti-Mouse CD49b Antibody [DX5] (AGEL1444)

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SKU AGEL1444
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Mouse
Host Species Rat
Isotype IgG2a,k
Clone DX5
Conjugation AF 647
€75 - €203
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Description

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GenieFluor 647 Anti-Mouse CD49b Antibody [DX5]

The Mouse CD49b Monoclonal Antibody (AF647 Conjugated, DX5, AGEL1444) from Assay Genie is a powerful tool for research involving CD49b, a cell surface marker essential for natural killer (NK) cell function and immune responses. This monoclonal antibody, conjugated with AF647 for fluorescent detection, offers high specificity and sensitivity in detecting CD49b in mouse samples.CD49b, also known as DX5, is a critical marker for identifying NK cells, a vital component of the innate immune system responsible for recognizing and eliminating infected or abnormal cells. The expression of CD49b is a key indicator of NK cell activity and function, making this antibody an indispensable resource for investigators studying immune responses, cancer immunotherapy, and infectious diseases in mouse models.

By targeting CD49b, researchers can analyze NK cell behavior, activation, and cytotoxicity, shedding light on the mechanisms underlying immune responses and potential therapeutic interventions. The Mouse CD49b Monoclonal Antibody (AF647 Conjugated, DX5, AGEL1444) facilitates accurate and precise detection of CD49b in various experimental settings, providing valuable insights into NK cell biology and immunological processes.

Product Title:GenieFluor 647 Anti-Mouse CD49b Antibody [DX5]
SKU:AGEL1444
Size:50 Tests, 100 Tests, 200 Tests
Clone No:DX5
Synonyms:Integrin alpha-2;CD49 antigen-like family member B;Collagen receptor;Platelet membrane glycoprotein Ia;GPIa;VLA-2 subunit alpha;CD49b;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgM, κ
Isotype Control:Genie Fluor 647 Rat IgM, κ Isotype Control[RTK2118]
Form:Liquid
Conjugation:Genie Fluor647
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q62469
Gene ID:16398
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:DX5 antigen has been recently characterized as CD49b. It is a 150 kD integrin α chain also known as α2 integrin, VLA-2 α chain, and integrin α2 chain. CD49b non-covalently associates with CD29 (β1 integrin) to form the CD49b/CD29 complex known as VLA-2, a receptor for collagen and laminin. CD49b is expressed on platelets, the majority of NK cells, NKT cells, and a small subset of CD8+ T cells (this population can be significantly increased following viral infection). DX5 is used for the identification and isolation of NK cells, and is especially useful for identifying NK cells in mice lacking the NK1.1 antigen.

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