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PE/Cyanine5 Anti-Mouse CD49b Antibody [DX5] (AGEL1449)

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SKU AGEL1449
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Mouse
Host Species Rat
Isotype IgG2a,k
Clone DX5
Conjugation PE/Cy5
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Description

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PE/Cyanine5 Anti-Mouse CD49b Antibody [DX5]

The Mouse CD49b Monoclonal Antibody PE-Cyanine5 Conjugated (DX5, AGL1449) is a vital tool for researchers studying immune cell populations and their functions. This antibody specifically targets CD49b, also known as DX5, a marker predominantly expressed on natural killer (NK) cells and a subset of T cells in mice.With its PE-Cyanine5 conjugation, this antibody allows for fluorescent detection and sorting of CD49b-expressing cells in flow cytometry and other analytical techniques. This enables researchers to accurately identify and characterize NK cells and CD49b+ T cells within complex immune cell populations, aiding in the investigation of immune responses, inflammation, and cancer immunology.

By using this monoclonal antibody, researchers can delve deeper into the roles and interactions of CD49b-expressing cells in various physiological and pathological conditions. Its applicability in mouse models makes it an invaluable asset for studies exploring the immune system's intricacies and potential therapeutic interventions.

Product Title:PE/Cyanine5 Anti-Mouse CD49b Antibody [DX5]
SKU:AGEL1449
Size:25µg, 100µg
Clone No:DX5
Synonyms:Integrin alpha-2;CD49 antigen-like family member B;Collagen receptor;Platelet membrane glycoprotein Ia;GPIa;VLA-2 subunit alpha;CD49b;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgM, κ
Isotype Control:PE/Cyanine5 Rat IgM, κ Isotype Control[RTK2118]
Form:Liquid
Conjugation:PE/Cyanine 5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q62469
Gene ID:16398
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:DX5 antigen has been recently characterized as CD49b. It is a 150 kD integrin α chain also known as α2 integrin, VLA-2 α chain, and integrin α2 chain. CD49b non-covalently associates with CD29 (β1 integrin) to form the CD49b/CD29 complex known as VLA-2, a receptor for collagen and laminin. CD49b is expressed on platelets, the majority of NK cells, NKT cells, and a small subset of CD8+ T cells (this population can be significantly increased following viral infection). DX5 is used for the identification and isolation of NK cells, and is especially useful for identifying NK cells in mice lacking the NK1.1 antigen.

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