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PE Anti-Mouse CD62L Antibody [Mel14] (AGEL0635)

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SKU AGEL0635
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Mouse
Host Species Rat
Isotype IgG2a,k
Clone Mel14
Conjugation PE
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Description

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PE Anti-Mouse CD62L Antibody [Mel14]

The Mouse CD62L Monoclonal Antibody PE-Conjugated (MEL-14) is a potent tool designed for research involving CD62L, a cell surface molecule crucial for lymphocyte homing and activation. This antibody, specifically engineered for mouse samples, is ideal for flow cytometry applications, allowing for the precise detection and analysis of CD62L expression in various cell populations.CD62L, also known as L-selectin, is a key adhesion molecule involved in the trafficking and activation of lymphocytes within the immune system.

Its role in facilitating lymphocyte migration to secondary lymphoid organs makes it a pivotal target for investigations in immunology, inflammation, and vaccine development. By utilizing the Mouse CD62L Monoclonal Antibody PE-Conjugated (MEL-14), researchers can gain valuable insights into the mechanisms governing immune cell movement and function, paving the way for advancements in immunotherapy and infectious disease research.

Product Title:PE Anti-Mouse CD62L Antibody [Mel14]
SKU:AGEL0635
Size:25µg, 100µg
Clone No:Mel14
Synonyms:L-selectin;Sell;CD62 antigen-like family member L;LAM-1;LECAM1;Lymph node homing receptor;Ly-22; CD62L;Lnhr;Ly22;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P18337
Gene ID:20343
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD62L is a 74-95 kD glycoprotein also known as L-selectin, LECAM-1, Ly-22, LAM-1, and MEL-14. It is a member of the selectin family and is expressed on the majority of B and naïve T cells, a subset of memory T cells, monocytes, granulocytes, most thymocytes, and a subset of NK cells. CD62L is important in lymphocyte homing to high endothelial venules (HEV) in peripheral lymph nodes and leukocyte 'rolling' on activated endothelium. CD62L also contributes to neutrophil emigration at inflammatory sites. CD62L is rapidly shed from lymphocytes and neutrophils upon cellular activation and the expression levels of CD62L (in conjunction with other markers) have been used to distinguish naïve, effector, and memory T cells. CD62L has been reported to interact with CD34, GlyCAM-1, and MAdCAM-1.

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