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PE/Cyanine5 Anti-Mouse CD62L Antibody [Mel14] (AGEL0638)

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SKU AGEL0638
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Mouse
Host Species Rat
Isotype IgG2a,k
Clone Mel14
Conjugation PE/Cy5
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Description

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PE/Cyanine5 Anti-Mouse CD62L Antibody [Mel14]

The Mouse CD62L Monoclonal Antibody PE/Cyanine5 Conjugated (ME14) is a cutting-edge tool for immunology research, particularly in studies involving CD62L, a crucial cell surface molecule involved in lymphocyte homing and activation. This monoclonal antibody, conjugated with PE/Cyanine5 for enhanced detection capabilities, is meticulously designed for precise targeting and visualization of CD62L in various cell types.CD62L, also known as L-selectin, plays a pivotal role in lymphocyte trafficking and adhesion to high endothelial venules in secondary lymphoid organs. By specifically recognizing and binding to CD62L, this antibody facilitates the accurate identification and analysis of lymphocytes expressing this critical marker. This feature makes it an invaluable tool for investigating immune responses, inflammatory processes, and lymphocyte migration patterns.

The conjugation of PE/Cyanine5 to the monoclonal antibody not only enhances its fluorescent properties but also ensures reliable and sensitive detection in flow cytometry and related applications. Researchers in immunology, inflammation, and cell biology can benefit from the precision and consistency offered by this specialized antibody in their investigations.By utilizing the Mouse CD62L Monoclonal Antibody PE/Cyanine5 Conjugated (ME14), scientists can delve deeper into the intricate mechanisms governing immune cell behavior and function, ultimately advancing our understanding of immune responses, inflammatory disorders, and potential therapeutic interventions.

Product Title:PE/Cyanine5 Anti-Mouse CD62L Antibody [Mel14]
SKU:AGEL0638
Size:25µg, 100µg
Clone No:Mel14
Synonyms:L-selectin;Sell;CD62 antigen-like family member L;LAM-1;LECAM1;Lymph node homing receptor;Ly-22; CD62L;Lnhr;Ly22;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE/Cyanine5 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE/Cyanine 5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P18337
Gene ID:20343
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD62L is a 74-95 kD glycoprotein also known as L-selectin, LECAM-1, Ly-22, LAM-1, and MEL-14. It is a member of the selectin family and is expressed on the majority of B and naïve T cells, a subset of memory T cells, monocytes, granulocytes, most thymocytes, and a subset of NK cells. CD62L is important in lymphocyte homing to high endothelial venules (HEV) in peripheral lymph nodes and leukocyte 'rolling' on activated endothelium. CD62L also contributes to neutrophil emigration at inflammatory sites. CD62L is rapidly shed from lymphocytes and neutrophils upon cellular activation and the expression levels of CD62L (in conjunction with other markers) have been used to distinguish naïve, effector, and memory T cells. CD62L has been reported to interact with CD34, GlyCAM-1, and MAdCAM-1.

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