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APC Anti-Mouse CD86 Antibody [GL-1] (AGEL0554)

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SKU AGEL0554
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Mouse
Host Species Rat
Isotype IgG2a,k
Clone GL-1
Conjugation APC
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Description

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APC Anti-Mouse CD86 Antibody [GL-1]

The Mouse CD86 Monoclonal Antibody (APC Conjugated, GL-1) is an essential tool for researchers studying the immune system in murine models. This antibody, derived from hybridoma cell culture, specifically targets CD86, a key co-stimulatory molecule involved in T cell activation. With its APC conjugation, this antibody is optimized for flow cytometry applications, enabling accurate and sensitive detection of CD86 expression on various immune cell populations.CD86, also known as B7-2, plays a critical role in regulating immune responses by providing co-stimulatory signals necessary for T cell activation and proliferation. Its expression on antigen-presenting cells is crucial for initiating and modulating adaptive immune responses.

By targeting CD86 with this monoclonal antibody, researchers can gain valuable insights into the immune regulatory mechanisms underlying conditions such as infectious diseases, autoimmune disorders, and transplant rejection.With its high specificity and sensitivity, the Mouse CD86 Monoclonal Antibody (APC Conjugated, GL-1) is a valuable asset for studies exploring the role of CD86 in immune system function and dysfunction. Whether investigating basic immunology principles or developing novel immunotherapies, this antibody provides a reliable tool for precise detection and characterization of CD86-expressing cells in murine experimental models.

Product Title:APC Anti-Mouse CD86 Antibody [GL-1]
SKU:AGEL0554
Size:25µg, 100µg
Clone No:GL-1
Synonyms:T-lymphocyte activation antigen CD86;Cd86;Activation B7-2 antigen;Early T-cell costimulatory molecule 1;ETC-1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:APC Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P42082
Gene ID:12524
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD86 is an 80 kD immunoglobulin superfamily member also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is a ligand of CD28 and CD152 (CTLA-4). CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce co-stimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.

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