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PE Anti-Mouse CD86 Antibody [GL-1] (AGEL0545)

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SKU AGEL0545
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Mouse
Host Species Rat
Isotype IgG2a,k
Clone GL-1
Conjugation PE
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Description

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PE Anti-Mouse CD86 Antibody [GL-1]

The Mouse CD86 Monoclonal Antibody (PE Conjugated, GL-1) is a cutting-edge tool for research involving CD86, a critical co-stimulatory molecule in the immune system. This antibody, produced through advanced monoclonal technology, is specifically designed for use in flow cytometry applications, providing high specificity and sensitivity in detecting CD86 expression on mouse cells.CD86, also known as B7-2, is a key regulator of T cell activation and immune response modulation. By binding to its receptor, CD28, CD86 plays a pivotal role in mediating T cell co-stimulation and promoting effective immune responses. Understanding the dynamics of CD86 expression and function is essential for unraveling the mechanisms underlying immune regulation, autoimmunity, and vaccine development.

The PE-conjugated GL-1 antibody offers researchers a reliable and versatile tool for probing CD86 expression levels in various cell populations, paving the way for in-depth studies of immune cell interactions, regulatory pathways, and therapeutic targets. With its high specificity and enhanced signal detection capabilities, this antibody is an indispensable asset for investigators in immunology, vaccine development, and inflammatory disease research. Explore the intricate world of immune regulation with the Mouse CD86 Monoclonal Antibody (PE Conjugated, GL-1) and unlock new insights into the complexities of immune function.

Product Title:PE Anti-Mouse CD86 Antibody [GL-1]
SKU:AGEL0545
Size:50 Tests, 100 Tests, 200 Tests
Clone No:GL-1
Synonyms:T-lymphocyte activation antigen CD86;Cd86;Activation B7-2 antigen;Early T-cell costimulatory molecule 1;ETC-1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P42082
Gene ID:12524
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD86 is an 80 kD immunoglobulin superfamily member also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is a ligand of CD28 and CD152 (CTLA-4). CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce co-stimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.

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