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PE Anti-Mouse CD86 Antibody [GL-1] (AGEL0553)

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SKU AGEL0553
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Mouse
Host Species Rat
Isotype IgG2a,k
Clone GL-1
Conjugation PE
€75 - €188
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Description

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PE Anti-Mouse CD86 Antibody [GL-1]

The Mouse CD86 Monoclonal Antibody (PE Conjugated) [GL-1] is a specialized tool for researchers investigating immune responses and cell signaling pathways. This antibody is perfectly suited for flow cytometry applications, allowing for precise detection and analysis of CD86, a crucial cell surface protein involved in antigen presentation and T cell activation.CD86, also known as B7-2, is a co-stimulatory molecule that plays a key role in regulating immune responses by interacting with CD28 on T cells. By targeting CD86 with this high-quality monoclonal antibody, researchers can gain valuable insights into the dynamics of immune cell interactions and potentially uncover new therapeutic targets for immune-related disorders.

With its PE conjugation, this antibody provides a fluorescent signal for easy visualization and quantification of CD86-expressing cells in complex samples. This makes it an essential tool for immunologists, cancer researchers, and scientists studying autoimmune diseases. By understanding the role of CD86 in immune regulation, this antibody opens up new avenues for exploring immune system function and designing targeted interventions for various diseases.

Product Title:PE Anti-Mouse CD86 Antibody [GL-1]
SKU:AGEL0553
Size:25µg, 100µg
Clone No:GL-1
Synonyms:T-lymphocyte activation antigen CD86;Cd86;Activation B7-2 antigen;Early T-cell costimulatory molecule 1;ETC-1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P42082
Gene ID:12524
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD86 is an 80 kD immunoglobulin superfamily member also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is a ligand of CD28 and CD152 (CTLA-4). CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce co-stimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.

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