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GenieFluor 647 Anti-Mouse F4/80 Antibody [CI:A3-1] (AGEL0575)

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SKU AGEL0575
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Mouse
Host Species Rat
Isotype IgG2a,k
Clone CI:A3-1
Conjugation AF 647
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Description

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GenieFluor 647 Anti-Mouse F4/80 Antibody [CI:A3-1]

The Mouse F4/80 Monoclonal Antibody (AF647 conjugated, clone: CI:A3-1, AGEL0575) is a powerful tool for immunological research, particularly in the study of macrophages and their activation states. This antibody recognizes the F4/80 protein, a well-established marker for mature tissue-resident macrophages in mice, and is conjugated to the AF647 fluorophore for enhanced detection.Macrophages, key players in the immune system, exhibit diverse functions depending on their activation state. The F4/80 antibody allows for the detection and characterization of macrophages in tissue samples, providing valuable insights into their roles in inflammation, tissue repair, and immune responses.

With its high specificity and sensitivity, this antibody is essential for dissecting the complex functions of macrophages in various physiological and pathological conditions.Whether investigating the dynamics of macrophage populations in disease progression, evaluating immune responses in experimental models, or exploring novel therapeutic targets in immunology, the Mouse F4/80 Monoclonal Antibody (AF647 conjugated, clone: CI:A3-1, AGEL0575) is a reliable reagent for precise and accurate immunofluorescence studies. Enhance your research capabilities with this cutting-edge antibody and unravel the mysteries of macrophage biology.

Product Title:GenieFluor 647 Anti-Mouse F4/80 Antibody [CI:A3-1]
SKU:AGEL0575
Size:25µg, 100µg
Clone No:CI:A3-1
Synonyms:Adhesion G protein-coupled receptor E1;Adgre1;Cell surface glycoprotein F4/80;EGF-like module receptor 1;Adgre1;Emr1; Gpf480;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:Genie Fluor 647 Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:Genie Fluor647
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q61549
Gene ID:13733
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:F4/80 is a 160 kD glycoprotein. It is characterized as a member of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family. F4/80, also known as EMR1 or Ly71, has been widely used as a murine macrophage marker, which is expressed on the majority of tissue macrophages including peritoneal macrophages, macrophages in lung, gut, thymus and red pulp of spleen (but not on the macrophages located in T cell areas of the spleen, lymph node and Peyer's patch), Kuffer cells, Langerhans cells, and bone marrow stromal cells. F4/80 has also been shown on a subset of dendritic cells. The biological ligand of F4/80 has not been identified, but it has been reported that F4/80 is required for induction of CD8+ T cells-mediated peripheral tolerance.

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