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APC Anti-Mouse F4/80 Antibody [CI:A3-1] (AGEL0046)

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SKU AGEL0046
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Mouse
Host Species Rat
Isotype IgG2b
Clone CI:A3-1
Conjugation APC
Applications FC
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Description

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APC Anti-Mouse F4/80 Antibody [CI:A3-1]

The APC-Conjugated Mouse F4/80 Monoclonal Antibody (CI:A3-1) is meticulously designed for research targeting F4/80, a crucial cell surface molecule widely expressed on tissue macrophages and essential for immune regulation. This monoclonal antibody, produced in mice, is highly specific to mouse F4/80 and validated for use in flow cytometry applications. The allophycocyanin (APC) conjugation ensures bright and stable red fluorescence, providing precise and reliable detection.F4/80, also known as EMR1 (Epidermal Growth Factor-like Module Containing Mucin-like Hormone Receptor-like 1), plays a vital role in macrophage function and immune homeostasis by regulating inflammation and promoting tissue repair. Its importance in immune response modulation makes it a valuable target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions.

The APC-Conjugated Mouse F4/80 Monoclonal Antibody (CI:A3-1) is an indispensable tool for researchers aiming to understand macrophage biology and develop therapies that modulate immune function.By enabling accurate and sensitive detection of F4/80, this antibody supports comprehensive studies of immune response pathways, contributing to the advancement of therapeutic strategies for autoimmune diseases, chronic inflammatory conditions, and cancer. Understanding the activity of F4/80 is crucial for the development of novel immunotherapies that leverage or modulate macrophage function in various disease contexts. This antibody is essential for advancing research in immunology and cancer.

Product Title:APC Anti-Mouse F4/80 Antibody [CI:A3-1]
SKU:AGEL0046
Size:50 Tests, 100 Tests, 200 Tests
Clone No:CI:A3-1
Synonyms:Adhesion G protein-coupled receptor E1;Adgre1;Cell surface glycoprotein F4/80;EGF-like module receptor 1;Adgre1;Emr1; Gpf480;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:APC Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q61549
Gene ID:13733
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:F4/80 is a 160 kD glycoprotein. It is characterized as a member of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family. F4/80, also known as EMR1 or Ly71, has been widely used as a murine macrophage marker, which is expressed on the majority of tissue macrophages including peritoneal macrophages, macrophages in lung, gut, thymus and red pulp of spleen (but not on the macrophages located in T cell areas of the spleen, lymph node and Peyer's patch), Kuffer cells, Langerhans cells, and bone marrow stromal cells. F4/80 has also been shown on a subset of dendritic cells. The biological ligand of F4/80 has not been identified, but it has been reported that F4/80 is required for induction of CD8+ T cells-mediated peripheral tolerance.

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