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Purified Anti-Mouse F4/80 Antibody [CI:A3-1] (AGEL0042)

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SKU AGEL0042
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Mouse
Host Species Rat
Isotype IgG2b
Clone CI:A3-1
Conjugation Unconjugated
Applications FC
Applications IF
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Description

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Purified Anti-Mouse F4/80 Antibody [CI:A3-1]

The Mouse F4/80 Monoclonal Antibody (CI:A3-1) is meticulously designed for research involving F4/80, a key cell surface molecule extensively expressed on tissue macrophages and implicated in immune regulation. This monoclonal antibody, produced in mice, is highly specific to mouse F4/80 and is validated for use in flow cytometry and immunohistochemistry applications. It binds specifically to the F4/80 protein, facilitating precise detection and analysis across various cell types, making it an ideal choice for studies in immunology and cancer research.F4/80, also known as EMR1 (Epidermal Growth Factor-like Module Containing Mucin-like Hormone Receptor-like 1), plays a crucial role in macrophage function and immune homeostasis by regulating inflammation and promoting tissue repair. Its significance in immune response modulation makes F4/80 a valuable target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions.

The Mouse F4/80 Monoclonal Antibody (CI:A3-1) is vital for researchers seeking to understand macrophage biology and develop therapies that harness or modulate immune function.By enabling accurate and sensitive detection of F4/80, this antibody supports comprehensive studies of immune response pathways, contributing to the advancement of therapeutic strategies for autoimmune diseases, chronic inflammatory conditions, and cancer. Understanding the activity of F4/80 is crucial for the development of novel immunotherapies that leverage or modulate macrophage function in various disease contexts. This antibody is essential for advancing research in immunology and cancer.

Product Title:Purified Anti-Mouse F4/80 Antibody [CI:A3-1]
SKU:AGEL0042
Size:25µg, 100µg
Clone No:CI:A3-1
Synonyms:Adhesion G protein-coupled receptor E1;Adgre1;Cell surface glycoprotein F4/80;EGF-like module receptor 1;Adgre1;Emr1; Gpf480;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:Purified Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:Unconjugated
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:Q61549
Gene ID:13733
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:F4/80 is a 160 kD glycoprotein. It is characterized as a member of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family. F4/80, also known as EMR1 or Ly71, has been widely used as a murine macrophage marker, which is expressed on the majority of tissue macrophages including peritoneal macrophages, macrophages in lung, gut, thymus and red pulp of spleen (but not on the macrophages located in T cell areas of the spleen, lymph node and Peyer's patch), Kuffer cells, Langerhans cells, and bone marrow stromal cells. F4/80 has also been shown on a subset of dendritic cells. The biological ligand of F4/80 has not been identified, but it has been reported that F4/80 is required for induction of CD8+ T cells-mediated peripheral tolerance.

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