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GenieFluor 488 Anti-Mouse/Human CD11b Antibody [M1/70] (AGEL1112)

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SKU AGEL1112
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Human
Reactivity Mouse
Host Species Rat
Isotype IgG2a,k
Clone M1/70
Conjugation AF 488
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Description

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GenieFluor 488 Anti-Mouse/Human CD11b Antibody [M1/70]

The Mouse-Human CD11b Monoclonal Antibody (AF488 Conjugated, M1/70) is a versatile tool for researchers studying the CD11b protein, a key marker for myeloid cells involved in immune responses. This antibody is specifically designed to detect CD11b in both mouse and human samples, making it ideal for cross-species research applications.The M1/70 antibody, conjugated with AF488 for fluorescent detection, offers high sensitivity and specificity in a variety of experimental techniques, including flow cytometry, immunofluorescence, and immunohistochemistry. Its ability to target CD11b allows for precise visualization and analysis of myeloid cells, aiding in the study of inflammation, infection, and immune system function.

CD11b, also known as integrin alpha M, plays a crucial role in cell adhesion and migration, particularly in the context of immune cell recruitment and phagocytosis. By targeting CD11b with this monoclonal antibody, researchers can gain insights into the behavior and function of myeloid cells in both normal physiological processes and disease states.Overall, the Mouse-Human CD11b Monoclonal Antibody (AF488 Conjugated, M1/70) provides researchers with a valuable tool for investigating the role of CD11b-expressing cells in immune responses, inflammation, and various pathological conditions. Its broad reactivity and reliable performance make it a valuable asset for studies in immunology, oncology, and related fields.

Product Title:GenieFluor 488 Anti-Mouse/Human CD11b Antibody [M1/70]
SKU:AGEL1112
Size:25µg, 100µg
Clone No:M1/70
Synonyms:Integrin alpha-M;Itgam;CD11 antigen-like family member B;CR-3 alpha chain;Leukocyte adhesion receptor MO1;CD11b;
Host Species:Rat
Reactivity:Human;Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:Genie Fluor 488 Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:Genie Fluor488
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P05555 P11215
Gene ID:16409,3684
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD11b is a 170 kD glycoprotein also known as αM integrin, Mac-1 α subunit, Mol, CR3, and Ly-40. CD11b is a member of the integrin family, primarily expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b non-covalently associates with CD18 (β2 integrin) to form Mac-1. Mac-1 plays an important role in cell-cell interaction by binding its ligands ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen.

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