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GenieFluor 647 Anti-Mouse/Human CD11b Antibody [M1/70] (AGEL1113)

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SKU AGEL1113
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Human
Reactivity Mouse
Host Species Rat
Isotype IgG2a,k
Clone M1/70
Conjugation AF 647
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Description

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GenieFluor 647 Anti-Mouse/Human CD11b Antibody [M1/70]

The Mouse-Human CD11b Monoclonal Antibody (AF647 Conjugated) - M1/70 (AG1113) is a specialized tool designed for scientists working with CD11b, a cell surface protein involved in immune responses. This monoclonal antibody, conjugated with AF647 for enhanced detection, is suitable for use in flow cytometry and immunofluorescence techniques. It specifically targets the CD11b antigen, allowing for precise analysis and visualization of this molecule on both mouse and human cells.CD11b, also known as integrin alpha M, plays a crucial role in various immune processes, including phagocytosis and cell adhesion. Its expression is often associated with myeloid cells, such as macrophages and neutrophils, indicating its role in innate immunity.

Researchers studying inflammation, infection, or immune cell function can benefit from utilizing this antibody to investigate CD11b expression patterns and dynamics in different experimental systems.With its high specificity and reliable performance, the Mouse-Human CD11b Monoclonal Antibody (AF647 Conjugated) - M1/70 (AG1113) is an essential reagent for immunology studies, including investigations into inflammatory diseases, host-pathogen interactions, and immune cell behavior. Its use can provide valuable insights into the functions and regulation of CD11b, contributing to a deeper understanding of immune responses and potential therapeutic targets.

Product Title:GenieFluor 647 Anti-Mouse/Human CD11b Antibody [M1/70]
SKU:AGEL1113
Size:25µg, 100µg
Clone No:M1/70
Synonyms:Integrin alpha-M;Itgam;CD11 antigen-like family member B;CR-3 alpha chain;Leukocyte adhesion receptor MO1;CD11b;
Host Species:Rat
Reactivity:Human;Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:Genie Fluor 647 Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:Genie Fluor647
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P05555 P11215
Gene ID:16409,3684
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD11b is a 170 kD glycoprotein also known as αM integrin, Mac-1 α subunit, Mol, CR3, and Ly-40. CD11b is a member of the integrin family, primarily expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b non-covalently associates with CD18 (β2 integrin) to form Mac-1. Mac-1 plays an important role in cell-cell interaction by binding its ligands ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen.

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