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GenieFluor 647 Anti-Mouse MHC II (I-A/I-E) Antibody [M5/114] (AGEL0508)

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SKU AGEL0508
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Mouse
Host Species Rat
Isotype IgG2a,k
Clone M5/114
Conjugation AF 647
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Description

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GenieFluor 647 Anti-Mouse MHC II (I-A/I-E) Antibody [M5/114]

The Mouse MHC II (I-A/I-E) Monoclonal Antibody (AF647 conjugated) (M5/114) is a powerful tool designed for research in the field of immunology and cell biology. This antibody, raised in mice, specifically targets the major histocompatibility complex class II molecules I-A and I-E in mice, enabling precise detection and analysis in various cell types.The MHC II complex plays a crucial role in the immune system by presenting antigens to T cells, thus initiating immune responses against foreign pathogens. The M5/114 antibody recognizes and binds to the MHC II (I-A/I-E) molecules, facilitating the study of antigen presentation and T cell activation processes. Its conjugation with AF647 allows for fluorescence detection, making it suitable for techniques such as flow cytometry and microscopy.

This antibody is a valuable tool for researchers exploring immune responses, antigen presentation, and adaptive immunity in mice. Its applications span from basic immunology research to studies investigating autoimmune diseases, infection, and vaccine development. By enabling precise visualization and analysis of MHC II expression, the Mouse MHC II (I-A/I-E) Monoclonal Antibody (AF647 conjugated) (M5/114) contributes to advancing our understanding of immune processes and holds promise for potential therapeutic interventions.

Product Title:GenieFluor 647 Anti-Mouse MHC II (I-A/I-E) Antibody [M5/114]
SKU:AGEL0508
Size:25µg, 100µg
Clone No:M5/114
Synonyms:H2-Ab1/Eb1;Major histocompatibility protein class II beta chain;MHC class II H2-IA-beta-psi;I-E beta MHC class II;MHC class II;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:Genie Fluor 647 Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:Genie Fluor647
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P14483 O78196
Gene ID:14961,14969
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:These class II molecules are expressed on antigen presenting cells (including B cells) and a subset of T cells from H-2b,d,q,r bearing mice and are involved in antigen presentation to T cells expressing CD3/TCR and CD4 proteins.

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