The MRGPRX3 Polyclonal Antibody (PACO02436) is a vital tool for studying MRGPRX3, a G protein-coupled receptor implicated in the sensing of various types of external stimuli, such as pain, itch, and inflammation. This antibody, derived from rabbit serum, exhibits high specificity for human MRGPRX3 and has been validated for use in Western blot applications. By binding to the MRGPRX3 protein, this antibody enables researchers to detect and analyze its expression in different cell types, making it perfect for investigations in the fields of sensory neuroscience and pain research.MRGPRX3, also known as Mas-related G protein-coupled receptor member X3, plays a crucial role in mediating sensory responses to diverse environmental stimuli, including noxious chemicals and inflammatory agents.
Understanding the function and regulation of MRGPRX3 is essential for unraveling its involvement in pathological conditions like chronic pain, pruritus, and inflammatory disorders. The MRGPRX3 Polyclonal Antibody provides a valuable tool for studying the biology of this receptor and its potential implications in the development of novel therapeutics targeting sensory disorders.
Antibody Name:
MRGPRX3 Antibody
Antibody SKU:
PACO02436
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IF
Recommended Dilutions:
WB:1:500-1:2000, IF:1:200-1:1000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human MRGX3.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
MRGPRX3: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins. Belongs to the G-protein coupled receptor 1 family. Mas subfamily.Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1Chromosomal Location of Human Ortholog: 11p15.1Cellular Component: integral to plasma membraneMolecular Function: G-protein coupled receptor activityBiological Process: G-protein coupled receptor protein signaling pathway
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the mas-related/sensory neuron specific subfamily of G protein coupled receptors. The encoded protein may be involved in sensory neuron regulation and in the modulation of pain. [provided by RefSeq, Oct 2009]
