Description
MRPL19 Antibody (PACO28342)
The MRPL19 Polyclonal Antibody (PAC028342) is a valuable tool for researchers studying mitochondrial ribosomal protein L19 (MRPL19), a key component of the mitochondrial ribosome involved in protein synthesis within the mitochondria. This antibody, produced in rabbits, exhibits strong reactivity with human samples and is validated for use in Western blot applications. By binding specifically to MRPL19, researchers can accurately detect and analyze this protein in a variety of cell types, making it an excellent choice for studies in molecular biology and mitochondrial research.
MRPL19 is essential for proper mitochondrial function and plays a vital role in the synthesis of proteins necessary for energy production within the cell. Dysregulation of MRPL19 has been linked to various mitochondrial disorders and diseases, making it a promising target for further investigation in the field of mitochondrial biology and related pathologies. By studying the function and expression of MRPL19, researchers can gain valuable insights into mitochondrial dysfunction and potentially develop new therapeutic strategies for mitochondrial-related diseases.
| Antibody Name: | MRPL19 Antibody (PACO28342) |
| Antibody SKU: | PACO28342 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human 39S ribosomal protein L19, mitochondrial protein (1-292AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: MRPL19 antibody at 2µg/ml Lane 1: MCF-7 whole cell lysate Lane 2: Mouse liver tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 34 kDa Observed band size: 34 kDa . |
 | Immunofluorescent analysis of Hela cells using PACO28342 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human placenta tissue using PACO28342 at dilution of 1:100. |
| Synonyms: | 39S ribosomal protein L19, mitochondrial (L19mt) (MRP-L19) (39S ribosomal protein L15, mitochondrial) (L15mt) (MRP-L15) (Mitochondrial large ribosomal subunit protein bL19m), MRPL19, KIAA0104 MRPL15 |
| UniProt Protein Function: | MRPL19: a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]Protein type: Translation; Ribosomal; MitochondrialChromosomal Location of Human Ortholog: 2p11.1-q11.2Cellular Component: mitochondrial inner membrane; mitochondrial large ribosomal subunit; nuclear membrane; nucleusMolecular Function: structural constituent of ribosome |
| UniProt Protein Details: | |
| NCBI Summary: | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P49406 |
| NCBI GenInfo Identifier: | 92090636 |
| NCBI Gene ID: | 9801 |
| NCBI Accession: | P49406.2 |
| UniProt Secondary Accession: | P49406,Q53TX9, Q96Q52 |
| UniProt Related Accession: | P49406 |
| Molecular Weight: | 33,535 Da |
| NCBI Full Name: | 39S ribosomal protein L19, mitochondrial |
| NCBI Synonym Full Names: | mitochondrial ribosomal protein L19 |
| NCBI Official Symbol: | MRPL19Â Â |
| NCBI Official Synonym Symbols: | RLX1; L19mt; MRPL15; RPML15; MRP-L15; MRP-L19Â Â |
| NCBI Protein Information: | 39S ribosomal protein L19, mitochondrial |
| UniProt Protein Name: | 39S ribosomal protein L19, mitochondrial |
| UniProt Synonym Protein Names: | 39S ribosomal protein L15, mitochondrial; L15mt; MRP-L15 |
| Protein Family: | 39S ribosomal protein |
| UniProt Gene Name: | MRPL19Â Â |
| UniProt Entry Name: | RM19_HUMAN |
| Antibodies |
| MRPL19 Antibody (PACO10577) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
