The MRPL21 Polyclonal Antibody (PACO01096) is an essential tool for researchers studying MRPL21, a protein involved in mitochondrial ribosomal assembly and translation. This antibody, developed using rabbit immunization, demonstrates high specificity to human samples and has been validated for use in Western blotting applications.MRPL21 plays a crucial role in cellular energy production and metabolism by facilitating protein synthesis within mitochondria. Dysregulation of MRPL21 has been implicated in various metabolic disorders and mitochondrial diseases, making it a promising target for therapeutic interventions.
By utilizing the MRPL21 Polyclonal Antibody, researchers can accurately detect and analyze MRPL21 protein expression in different cell types, allowing for a deeper understanding of its biological function and potential implications in disease pathology. This antibody is a valuable tool for studies in molecular biology, mitochondrial research, and drug development aimed at targeting mitochondrial dysfunction-related diseases.
Antibody Name:
MRPL21 Antibody
Antibody SKU:
PACO01096
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the Internal region of human MRP-L21.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
MRPL21; 39S ribosomal protein L21; mitochondrial; L21mt; MRP-L21
UniProt Protein Function:
MRPL21: a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]Protein type: Ribosomal; MitochondrialChromosomal Location of Human Ortholog: 11q13.3Cellular Component: mitochondrial inner membrane; ribosomeMolecular Function: structural constituent of ribosomeBiological Process: mitochondrial translation; organelle organization and biogenesis
UniProt Protein Details:
NCBI Summary:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]
