The MRPL21 Polyclonal Antibody (PAC010579) is a valuable tool for researchers studying MRPL21, a key player in mitochondrial ribosome biogenesis. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding to the MRPL21 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in the fields of molecular biology and cellular metabolism.MRPL21, also known as mitochondrial ribosomal protein L21, is essential for the assembly and function of mitochondrial ribosomes, which are responsible for protein synthesis within the mitochondria.
Dysregulation of MRPL21 has been linked to various diseases, including metabolic disorders and mitochondrial dysfunction. By studying the role of MRPL21 in cellular processes, researchers can gain insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets for intervention.
mitochondrial ribosomal protein L21;MRPL21;L21mt;MGC62013;MRP-L21 ;
UniProt Protein Function:
MRPL21: a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]Protein type: Ribosomal; MitochondrialChromosomal Location of Human Ortholog: 11q13.3Cellular Component: mitochondrial inner membrane; ribosomeMolecular Function: structural constituent of ribosomeBiological Process: mitochondrial translation; organelle organization and biogenesis
UniProt Protein Details:
NCBI Summary:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]
