The MRPL3 Monoclonal Antibody (PACO10584) is a valuable tool for research involving MRPL3, a mitochondrial ribosomal protein essential for protein synthesis within the mitochondria. This antibody, produced using hybridoma technology, has been validated for use in various applications such as immunofluorescence, immunoprecipitation, and ELISA. It specifically binds to the MRPL3 protein, allowing for accurate detection and analysis in a variety of cell types.MRPL3 plays a key role in mitochondrial protein synthesis and is essential for maintaining mitochondrial function. Dysregulation of MRPL3 has been implicated in a variety of diseases, including neurodegenerative disorders and cancer.
By studying the function of MRPL3 using this antibody, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets.Overall, the MRPL3 Monoclonal Antibody (PACO10584) is a versatile tool for researchers interested in exploring the role of MRPL3 in health and disease. Its high specificity and sensitivity make it an ideal choice for a wide range of experimental settings, making it a valuable addition to any research laboratory focused on mitochondrial biology and related fields.
mitochondrial ribosomal protein L3;MRPL3;MRL3;RPML3 ;
UniProt Protein Function:
MRPL3: Defects in MRPL3 are the cause of combined oxidative phosphorylation deficiency type 9 (COXPD9). A mitochondrial disease characterized by failure to thrive, poor feeding, hypertrophic cardiomyopathy, hepatomegaly, and psychomotor retardation. Death in infancy has been observed in some cases. Belongs to the ribosomal protein L3P family.Protein type: Mitochondrial; Ribosomal; Translation; RNA-bindingChromosomal Location of Human Ortholog: 3q21-q23Cellular Component: mitochondrial inner membrane; mitochondrial large ribosomal subunitMolecular Function: structural constituent of ribosome; RNA bindingBiological Process: mitochondrial translation; translation; organelle organization and biogenesisDisease: Combined Oxidative Phosphorylation Deficiency 9
UniProt Protein Details:
NCBI Summary:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L3P ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 13q. [provided by RefSeq, Jul 2008]
