The MRPL49 Polyclonal Antibody (PAC010593) is a valuable tool for researchers studying MRPL49, a mitochondrial ribosomal protein involved in protein synthesis within the mitochondria. This antibody, derived from rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blotting.MRPL49 plays a key role in mitochondrial function and has been linked to various diseases and disorders, including mitochondrial dysfunction, neurodegenerative diseases, and cancer.
By targeting MRPL49 with this antibody, researchers can gain insights into its function and potential implications in disease pathology.This antibody is suitable for use in immunology, cancer research, and mitochondrial biology studies, providing researchers with a reliable tool for detecting and analyzing MRPL49 in various cell types. Gain a deeper understanding of MRPL49 and its involvement in disease processes with the use of this high-quality antibody.
mitochondrial ribosomal protein L49;MRPL49;C11orf4;L49mt;MGC10656;NOF;NOF1 ;
UniProt Protein Function:
MRPL49: a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. Pseudogenes corresponding to this gene are found on chromosomes 5q and 8p. [provided by RefSeq, May 2011]Protein type: Ribosomal; Translation; MitochondrialChromosomal Location of Human Ortholog: 11q13Cellular Component: mitochondrial inner membrane; mitochondrial large ribosomal subunit; mitochondrial ribosomeMolecular Function: protein binding; structural constituent of ribosomeBiological Process: mitochondrial translation; organelle organization and biogenesis
UniProt Protein Details:
NCBI Summary:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. Pseudogenes corresponding to this gene are found on chromosomes 5q and 8p. [provided by RefSeq, May 2011]
