The MRPL50 Polyclonal Antibody (PACO38798) is a valuable tool for researchers studying MRPL50, a mitochondrial ribosomal protein involved in protein synthesis within the mitochondria. This antibody, produced in rabbits, has been validated for use in Western blot applications and is highly reactive with human samples.MRPL50 plays a crucial role in maintaining mitochondrial function and has been implicated in various diseases, including cancer and neurodegenerative disorders.
By targeting MRPL50 with this antibody, researchers can investigate its role in mitochondrial protein synthesis and potentially uncover new insights into mitochondrial dysfunction and its connection to disease pathology.In summary, the MRPL50 Polyclonal Antibody (PACO38798) is a reliable antibody for studying the function of MRPL50 in mitochondrial protein synthesis, making it a valuable tool for research in areas such as cancer biology and neurodegenerative diseases.
Antibody Name:
MRPL50 Antibody (PACO38798)
Antibody SKU:
PACO38798
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human 39S ribosomal protein L50, mitochondrial protein (1-158AA)
39S ribosomal protein L50, mitochondrial (L50mt) (MRP-L50) (Mitochondrial large ribosomal subunit protein mL50), MRPL50
UniProt Protein Function:
MRPL50: 2 isoforms of the human protein are produced by alternative splicingChromosomal Location of Human Ortholog: 9q31.1Cellular Component: mitochondrial inner membrane
UniProt Protein Details:
NCBI Summary:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a putative 39S subunit protein and belongs to the L47P ribosomal protein family. Pseudogenes corresponding to this gene are found on chromosomes 2p, 2q, 5p, and 10q. [provided by RefSeq, Jul 2008]
