The MRPS34 Antibody (PAC010614) is a polyclonal antibody designed for research involving MRPS34, a protein involved in mitochondrial ribosome biogenesis. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications such as Western blot and immunofluorescence.MRPS34 is a critical protein in the assembly of the mitochondrial ribosome, which is essential for the translation of mitochondrial genes. Dysfunction in MRPS34 has been implicated in various mitochondrial diseases and disorders, making it a key target for research in the fields of biochemistry and cell biology.
By utilizing the MRPS34 Antibody, researchers can detect and analyze the expression levels of MRPS34 in different cell types, aiding in the understanding of its function in mitochondrial ribosome biogenesis. This antibody is a valuable tool for studies focused on mitochondrial dysfunction, genetic disorders, and potential therapeutic interventions targeting mitochondrial protein synthesis.
mitochondrial ribosomal protein S34;MRPS34;MGC2616;MRP-S12;MRP-S34;MRPS12 ;
UniProt Protein Function:
MRPS34: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.Chromosomal Location of Human Ortholog: 16p13.3Cellular Component: mitochondrial inner membrane; mitochondrionBiological Process: mitochondrial translation
UniProt Protein Details:
NCBI Summary:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
