The MSMO1 Monoclonal Antibody (PAC019615) is a powerful tool for research involving MSMO1, a protein associated with the mevalonate pathway and cholesterol biosynthesis. This antibody, produced using state-of-the-art technology, specifically targets MSMO1 and is highly reactive with human samples. Validated for use in immunofluorescence and immunohistochemistry applications, it enables precise detection and localization of MSMO1 in various cell and tissue types.MSMO1 is a key enzyme involved in the biosynthesis of cholesterol and other essential molecules in the mevalonate pathway. Dysregulation of this pathway has been linked to various metabolic disorders, making MSMO1 a promising target for research in lipid metabolism and related diseases.
By studying the expression and function of MSMO1, researchers can gain valuable insights into the mechanisms underlying dyslipidemia, atherosclerosis, and other metabolic conditions.Investigating the role of MSMO1 in cellular physiology and disease pathology is crucial for developing targeted therapies and diagnostic tools. The MSMO1 Monoclonal Antibody provides researchers with a reliable means of studying this important protein, facilitating advancements in the fields of biochemistry, molecular biology, and metabolic research.
Antibody Name:
MSMO1 Antibody (PACO19615)
Antibody SKU:
PACO19615
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human MSMO1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO19615(MSMO1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO19615(MSMO1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Sterol-C4-mehtyl oxidase-like protein was isolated based on its similarity to the yeast ERG25 protein. It contains a set of putative metal binding motifs with similarity to that seen in a family of membrane desaturases-hydroxylases. The protein is localized to the endoplasmic reticulum membrane and is believed to function in cholesterol biosynthesis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Synonyms:
methylsterol monooxygenase 1
UniProt Protein Function:
SC4MOL: Sterol-C4-mehtyl oxidase-like protein was isolated based on its similarity to the yeast ERG25 protein. It contains a set of putative metal binding motifs with similarity to that seen in a family of membrane desaturases-hydroxylases. The protein is localized to the endoplasmic reticulum membrane and is believed to function in cholesterol biosynthesis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]Protein type: EC 1.14.13.72; Oxidoreductase; Membrane protein, multi-pass; Endoplasmic reticulum; Lipid Metabolism - steroid biosynthesis; Membrane protein, integralChromosomal Location of Human Ortholog: 4q32-q34Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; plasma membraneMolecular Function: C-4 methylsterol oxidase activityBiological Process: cholesterol biosynthetic process; fatty acid metabolic process; steroid metabolic process
UniProt Protein Details:
NCBI Summary:
Sterol-C4-mehtyl oxidase-like protein was isolated based on its similarity to the yeast ERG25 protein. It contains a set of putative metal binding motifs with similarity to that seen in a family of membrane desaturases-hydroxylases. The protein is localized to the endoplasmic reticulum membrane and is believed to function in cholesterol biosynthesis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
