The MVP Monoclonal Antibody (CAB1039) is a high-quality antibody developed for reliable detection and analysis of target proteins. This polyclonal antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blot and immunohistochemistry.MVP, also known as Major Vault Protein, is involved in multidrug resistance and is associated with poor prognosis in cancer patients. Research on MVP is essential for understanding drug resistance mechanisms and developing new approaches to overcome this challenge in cancer treatment.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
MVP Monoclonal Antibody
SKU:
CAB1039
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Clone Number:
ARC1855
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
LRP, VAULT1, MVP
Positive Sample:
HT-29, A549, Mouse lung, Mouse liver, Rat lung, Rat kidney
Cellular Localization:
Cytoplasm, Nucleus, Nuclear Pore Complex.
Calculated MW:
99kDa
Observed MW:
99kDa
This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene.
Purification Method
Affinity purification
Gene ID
9961
RRID
AB_2861492
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using MVP Rabbit mAb (CAB1039) at 1:500 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 10s.
Western blot analysis of lysates from Rat kidney, using MVP Rabbit mAb (CAB1039) at 1:500 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s.
