Description
Myc (Phospho-Ser62)Transcription Factor Activity Assay
The MYC Phospho-Ser62 Transcription Factor Activity Assay Kit is a cutting-edge tool designed for the accurate measurement of MYC transcription factor activity in cell lysates. This assay kit offers high sensitivity and specificity, providing researchers with reliable and reproducible results for a variety of experimental settings.MYC is a key transcription factor that plays a critical role in regulating cell growth, proliferation, and survival. Phosphorylation of MYC at Ser62 is known to enhance its transcriptional activity, making this kit an invaluable resource for studying the impact of post-translational modifications on MYC function.
This assay kit is essential for researchers investigating cancer, genetic disorders, and other diseases where MYC dysregulation is a factor. With its user-friendly protocol and robust performance, the MYC Phospho-Ser62 Transcription Factor Activity Assay Kit is a must-have tool for studying MYC biology and potential therapeutic interventions.
| Product Name: | Myc (Phospho-Ser62)Transcription Factor Activity Assay |
| Product Code: | TFAB00036 |
| Target: | Myc (Phospho-Ser62) |
| Synonyms: | Class E basic helix-loop-helix protein 39, bHLHe39, Proto-oncogene c-Myc, Transcription factor p64 |
| Reactivity: | Human, Mouse |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie Myc (Phospho-Ser62) transcription factor activity assay allows for the detection and qualitative analysis of Myc (Phospho-Ser62) active transcription factors in eukaryotic nuclear or cell lysates.
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | Myc: a proto-oncogenic transcription factor that plays a role in cell proliferation, apoptosis and in the development of human tumors. Seems to activate the transcription of growth-related genes. |
| UniProt Protein Details: | Protein type:DNA-binding; Nucleolus; Oncoprotein; Transcription factor Chromosomal Location of Human Ortholog: 8q24.21 Cellular Component: nucleoplasm; protein complex; nucleolus; nucleus; cytosol Molecular Function:protein dimerization activity; protein binding; DNA binding; protein complex binding; transcription factor binding; transcription factor activity Biological Process: oxygen transport; cellular iron ion homeostasis; positive regulation of transcription, DNA-dependent; positive regulation of caspase activity; negative regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; chromosome organization and biogenesis; positive regulation of fibroblast proliferation; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; response to gamma radiation; cell cycle arrest; response to drug; transcription initiation from RNA polymerase II promoter; Notch signaling pathway; regulation of telomere maintenance; transcription, DNA-dependent; MAPKKK cascade; negative regulation of cell division; negative regulation of stress-activated MAPK cascade; negative regulation of monocyte differentiation; chromatin remodeling; ureteric bud branching; regulation of gene expression; negative regulation of fibroblast proliferation; energy reserve metabolic process; gene expression; positive regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus; positive regulation of epithelial cell proliferation; negative regulation of apoptosis Disease: Burkitt Lymphoma |
| NCBI Summary: | The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P01106 |
| NCBI GenInfo Identifier: | 127619 |
| NCBI Gene ID: | 4609 |
| NCBI Accession: | P01106.1 |
| UniProt Secondary Accession: | P01106,P01107, Q14026, A8WFE7, |
| UniProt Related Accession: | P01106 |
| Molecular Weight: | 439 |
| NCBI Full Name: | Myc proto-oncogene protein |
| NCBI Synonym Full Names: | v-myc avian myelocytomatosis viral oncogene homolog |
| NCBI Official Symbol: | MYCÂ Â |
| NCBI Official Synonym Symbols: | MRTL; MYCC; c-Myc; bHLHe39Â Â |
| NCBI Protein Information: | myc proto-oncogene protein; proto-oncogene c-Myc; transcription factor p64; class E basic helix-loop-helix protein 39; avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog; myc-related translation/localization regulatory factor |
| UniProt Protein Name: | Myc proto-oncogene protein |
| UniProt Synonym Protein Names: | Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64 |
| Protein Family: | Myc protein |
| UniProt Gene Name: | MYCÂ Â |
| UniProt Entry Name: | MYC_HUMAN |
