The MyD88 Monoclonal Antibody (CAB21905) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody is produced using state-of-the-art monoclonal antibody technology, ensuring high specificity and sensitivity in detection assays.MyD88 is a crucial adaptor protein involved in Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) signaling pathways, playing a pivotal role in activating pro-inflammatory responses against pathogens. Dysregulation of MyD88 signaling has been linked to various inflammatory diseases, autoimmune disorders, and cancer.This monoclonal antibody has been rigorously validated for use in various applications, including Western blotting, immunofluorescence, and immunoprecipitation.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Mouse, Rat samples.
Product Name:
MyD88 Monoclonal Antibody
SKU:
CAB21905
Size:
20μL, 100μL
Reactivity:
Mouse, Rat
Clone Number:
ARC52509
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
WM1, IMD68, MYD88D, MyD88
Positive Sample:
Mouse lung, Rat lung
Cellular Localization:
Cytoplasm.
Calculated MW:
33kDa
Observed MW:
33kDa
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants.
Purification Method
Affinity purification
Gene ID
4615
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% Sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse lung, using MyD88 Rabbit mAb (CAB21905) at1:2000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 180s.
Western blot analysis of lysates from Rat lung, using MyD88 Rabbit mAb (CAB21905) at1:2000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 90s.
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