Description
MYL12A/MYL12B/MYL9 Antibody (PACO03361)
The MYL12A, MYL12B, MYL9 Antibody (PAC03361) is a polyclonal antibody designed for research involving the MYL12A, MYL12B, and MYL9 proteins, which are essential for regulating smooth muscle contraction. Raised in rabbits, this antibody is highly reactive with human samples and is validated for use in applications such as Western blot and immunohistochemistry.These proteins play a crucial role in muscle contraction and cell motility, making them important targets for research in cell biology and muscle function. The MYL12A, MYL12B, and MYL9 Antibody binds specifically to these proteins, allowing for their detection and analysis in various cell types and tissues.
This antibody is ideal for studies in fields such as cardiovascular research, muscle physiology, and smooth muscle disorders.Understanding the function and regulation of MYL12A, MYL12B, and MYL9 is essential for unraveling the mechanisms underlying muscle contraction and cell movement. Research on these proteins may provide insights into diseases related to muscle dysfunction, such as cardiovascular diseases and muscular disorders. The MYL12A, MYL12B, and MYL9 Antibody is a valuable tool for investigating the roles of these proteins in health and disease.
| Antibody Name: | MYL12A/MYL12B/MYL9 Antibody |
| Antibody SKU: | PACO03361 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | IHC:1:100-1:300, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from human MLC-2 around the non-phosphorylation site of T17/S18. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | MYL12A; MLCB; MRLC3; RLC; Myosin regulatory light chain 12A; MLC-2B; Myosin RLC; Myosin regulatory light chain 2; nonsarcomeric; Myosin regulatory light chain MRLC3; MYL12B; MRLC2; MYLC2B; Myosin regulatory light chain 12B; MLC-2A; MLC-2; M |
| UniProt Protein Function: | MRLC3: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. Myosin is an hexamer of 2 heavy chains and 4 light chains. |
| UniProt Protein Details: | Protein type:Contractile Chromosomal Location of Human Ortholog: 18p11.31 Cellular Component: myosin II complex; stress fiber; cytosol; Z disc Molecular Function:protein binding; glutamate receptor binding; calcium ion binding Biological Process: axon guidance; regulation of cell shape; ephrin receptor signaling pathway |
| NCBI Summary: | This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF)/Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8.[provided by RefSeq, Dec 2014] |
| UniProt Code: | P19105 |
| NCBI GenInfo Identifier: | 127169 |
| NCBI Gene ID: | 10627 |
| NCBI Accession: | P19105.2 |
| UniProt Secondary Accession: | P19105,Q53X45, |
| UniProt Related Accession: | P19105 |
| Molecular Weight: | 171 |
| NCBI Full Name: | Myosin regulatory light chain 12A |
| NCBI Synonym Full Names: | myosin, light chain 12A, regulatory, non-sarcomeric |
| NCBI Official Symbol: | MYL12AÂ Â |
| NCBI Official Synonym Symbols: | MLCB; MRCL3; MRLC3; MYL2B; MLC-2B; HEL-S-24Â Â |
| NCBI Protein Information: | myosin regulatory light chain 12A; myosin RLC; myosin regulatory light chain 3; epididymis secretory protein Li 24; myosin regulatory light chain MRLC3; myosin regulatory light chain 2, nonsarcomeric; myosin, light polypeptide, regulatory, non-sarcomeric |
| UniProt Protein Name: | Myosin regulatory light chain 12A |
| UniProt Synonym Protein Names: | Epididymis secretory protein Li 24; HEL-S-24; MLC-2B; Myosin RLC; Myosin regulatory light chain 2, nonsarcomeric; Myosin regulatory light chain MRLC3 |
| Protein Family: | C-type mannose receptor |
| UniProt Gene Name: | MYL12AÂ Â |
| UniProt Entry Name: | ML12A_HUMAN |
