Description
NARFL Antibody (PACO13531)
The NARFL Polyclonal Antibody (PAC013531) is a specialized tool for researchers studying the NARFL protein, an essential component of the iron-sulfur (Fe-S) cluster assembly pathway in mitochondria. This antibody is produced in rabbits and is highly specific to human samples, making it a reliable choice for Western blot applications. By binding to NARFL, this antibody allows for accurate detection and analysis of the protein in various cell types, making it a valuable tool for studies in mitochondrial biology and related diseases.NARFL is a crucial player in maintaining mitochondrial function and energy production by facilitating the assembly of Fe-S clusters, which are essential for the activity of numerous mitochondrial enzymes.
Dysregulation of NARFL has been implicated in mitochondrial diseases and metabolic disorders, highlighting its importance in cellular health. By elucidating the role of NARFL, researchers can gain insights into mitochondrial dysfunction and potentially identify new therapeutic targets for diseases associated with mitochondrial impairment.
| Antibody Name: | NARFL Antibody (PACO13531) |
| Antibody SKU: | PACO13531 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human NARFL-Specific |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | nuclear prelamin A recognition factor-like;NARFL;FLJ21988;HPRN;IOP1;LET1L;PRN ; |
| UniProt Protein Function: | NARFL: Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect. Belongs to the NARF family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 16p13.3 Biological Process: iron-sulfur cluster assembly; oxygen homeostasis; regulation of transcription, DNA-dependent; response to hypoxia |
| UniProt Code: | Q9H6Q4 |
| NCBI GenInfo Identifier: | 74733617 |
| NCBI Gene ID: | 64428 |
| NCBI Accession: | Q9H6Q4.1 |
| UniProt Secondary Accession: | Q9H6Q4,Q53GC6, Q96S10, Q9H6J8, A1L385, B3KTJ3, |
| UniProt Related Accession: | Q9H6Q4 |
| Molecular Weight: | 42,010 Da |
| NCBI Full Name: | Cytosolic Fe-S cluster assembly factor NARFL |
| NCBI Synonym Full Names: | nuclear prelamin A recognition factor like |
| NCBI Official Symbol: | NARFLÂ Â |
| NCBI Official Synonym Symbols: | PRN; HPRN; IOP1; NAR1; LET1LÂ Â |
| NCBI Protein Information: | cytosolic Fe-S cluster assembly factor NARFL |
| UniProt Protein Name: | Cytosolic Fe-S cluster assembly factor NARFL |
| UniProt Synonym Protein Names: | Iron-only hydrogenase-like protein 1; IOP1; Nuclear prelamin A recognition factor-like protein; Protein related to Narf |
| Protein Family: | Cytosolic Fe-S cluster assembly factor |
| UniProt Gene Name: | NARFLÂ Â |
| UniProt Entry Name: | NARFL_HUMAN |
